Integrative Physiological and Behavioral Science

, Volume 33, Issue 4, pp 315–320

Approximate entropy and point correlation dimension of heart rate variability in healthy subjects

  • Robert J. Storella
  • Harrison W. Wood
  • Kenneth M. Mills
  • Jørgen K. Kanters
  • Michael V. Højgaard
  • Niels-Henrik Holstein-Rathlou
Papers

DOI: 10.1007/BF02688699

Cite this article as:
Storella, R.J., Wood, H.W., Mills, K.M. et al. Integrative Physiological and Behavioral Science (1998) 33: 315. doi:10.1007/BF02688699

Abstract

The contribution of nonlinear dynamics to heart rate variability in healthy humans was examined using surrogate data analysis. Several measures of heart rate variability were used and compared. Heart rates were recorded for three hours and original data sets of 8192 R-R intervals created. For each original data set (n=34), three surrogate data sets were made by shuffling the order of the R-R intervals while retaining their linear correlations. The difference in heart rate variability between the original and surrogate data sets reflects the amount of nonlinear structure in the original data set. Heart rate variability was analyzed by two different nonlinear methods, point correlation dimension and approximate entropy. Nonlinearity, though under 10 percent, could be detected with both types of heart rate variability measures. More importantly, not only were the correlations between these measures and the standard deviation of the R-R intervals weak, the correlation among the nonlinear measures themselves was also weak (generally less than 0.6). This suggests that in addition to standard linear measures of heart rate variability, the use of multiple nonlinear measures of heart rate variability might be useful in monitoring heart rate dynamics.

Copyright information

© Springer 1998

Authors and Affiliations

  • Robert J. Storella
    • 1
  • Harrison W. Wood
    • 1
  • Kenneth M. Mills
    • 1
  • Jørgen K. Kanters
    • 2
    • 3
  • Michael V. Højgaard
    • 2
    • 3
  • Niels-Henrik Holstein-Rathlou
    • 2
  1. 1.Department of Anesthesiology, MCP-Hahnemann School of MedicineAllegheny University of the Health SciencesPhiladelphia
  2. 2.Department of Medical PhysiologyUniversity of CopenhagenCopenhagen NDenmark
  3. 3.Department of Internal Medicine, Coronary Care UnitElsinore HospitalHelsingørDenmark

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