Immunologic Research

, Volume 37, Issue 1, pp 1–16

Decoding IgE Fc receptors

  • Ming Zhang
  • Richard F. Murphy
  • Devendra K. Agrawal
Article

DOI: 10.1007/BF02686092

Cite this article as:
Zhang, M., Murphy, R.F. & Agrawal, D.K. Immunol Res (2007) 37: 1. doi:10.1007/BF02686092
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Abstract

Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcεRI and low-affinity FcεRII (CD23). Allergen-induced IgE-occupied EcεRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcεRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcεRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IGE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.

Key words

AllergyAnti-IgE therapyCD23FcεRIFcεRIIIgE receptorsImmunoglobulinsITAMsITIMsLipid raft segregationRabGEF1

Copyright information

© Humana Press Inc 2007

Authors and Affiliations

  • Ming Zhang
    • 1
  • Richard F. Murphy
    • 2
  • Devendra K. Agrawal
    • 1
    • 2
    • 3
  1. 1.Department of Medical Microbiology and ImmunologyCreighton University School of MedicineOmaha
  2. 2.Department of Biomedical SciencesCreighton University of Medicine
  3. 3.Department of International MedicineCreighton University School of MedicineOmaha