Bulletin of Experimental Biology and Medicine

, Volume 130, Issue 1, pp 633–635

Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine

  • T. G. Pukhal’skaya
  • O. A. Kolosova
  • M. Y. Men’shikov
  • A. M. Vein
General Pathology and Pathological Physiology

DOI: 10.1007/BF02682090

Cite this article as:
Pukhal’skaya, T.G., Kolosova, O.A., Men’shikov, M.Y. et al. Bull Exp Biol Med (2000) 130: 633. doi:10.1007/BF02682090

Abstract

Flunarizine and cinnarizine (IC50 6.8×10−6 and 2.8×10−5 M, respectively) inhibited3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity as an inductor of serotonin release.

Key words

migraineplateletsaggregationserotonin uptake and releaseflunarizinecinnarizine

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • T. G. Pukhal’skaya
    • 1
  • O. A. Kolosova
    • 2
  • M. Y. Men’shikov
    • 3
  • A. M. Vein
    • 2
  1. 1.Institute of PharmacologyRussian Academy of Medical SciencesMoscow
  2. 2.Department of Nervous DiseasesM. I. Sechenov Moscow Medical AcademyMoscow
  3. 3.Institute ofExperimental Cardiology, Russian Cardiology Research-and-Production ComplexRussian Ministry of HealthMoscow