Annals of Biomedical Engineering

, Volume 24, Issue 4, pp 457–473

1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors

  • Rakesh K. Jain
Whitaker Lecture

DOI: 10.1007/BF02648108

Cite this article as:
Jain, R.K. Ann Biomed Eng (1996) 24: 457. doi:10.1007/BF02648108


To reach cancer cells in a tumor, a blood-borne therapeutic agent must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then to integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.


Tumor microcirculationAngiogenesisBlood flowVascular PermeabilityDiffusion and convectionReceptor-ligand bindingInterstitial pressureLymphaticsCell adhesion and deformationCancer detection and treatment

Copyright information

© Biomedical Engineering Society 1996

Authors and Affiliations

  • Rakesh K. Jain
    • 1
  1. 1.Department of Radiation Oncology, Massachusetts General HospitalHarvard Medical SchoolBoston