The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect on blood lipid peroxidation products (LP) and lipid profile of diabetic patients. Thirty-five diabetics(D) were supplemented withdl-α-tocopherol (E) capsule (orally, 100 IU/d) or placebo (P) for three months in double-blind clinical trials. Plasma E was analyzed by HPLC and LP by the thiobarbituric acid-reactivity; serum lipids by auto-analyzer. Data were analyzed using pairedt-test and Wilcoxon Signed Rank Test. Vitamin E supplementation significantly lowered LP and lipid levels in diabetic patients; there were no differences in these parameters after P supplementation. There were no differences in the duration of diabetes and ages of D between P-and E-supplemented groups. This study suggests that vitamin E supplementation significantly lowers blood LP and lipid levels in diabetic patients.
- Lyons, T.J. (1991) Oxidized Low Density Lipoproteins: A Role in the Pathogenesis of Atherosclerosis in Diabetes?,Diabetic Med. 8, 411–419.
- Oberly, L.W. (1988) Free Radicals and Diabetes,Free Rad. Biol. Med. 5, 113–124. CrossRef
- Baynes, J.W. (1991) Role of Oxidative Stress in Development of Complications in Diabetes,Diabetes 40, 405–411. CrossRef
- Sato, Y., Hotta, N., Sakamoto, N., Matsuoka, S., Ohishi, N., and Yagi, K. (1979) Lipid Peroxide Level in Plasma of Diabetic Patients,Biochem. Med. 21, 104–107. CrossRef
- Kaji, H., Kurasaki, M., Ito, K., Saito, T., Saito, K., Niioka, T., Kojima, Y., Ohsaki, Y., Ide, H., Tsuji, M., Kondo, T., and Kawakami, Y. (1985) Increased Lipoperoxide Value and Glutathione Peroxidase Activity in Blood Plasma of Type 2 (Non-Insulin-Dependent) Diabetic Women,Klin. Wochenschr. 63, 765–768. CrossRef
- Niimi, K., and Hiraiwa, N. (1985) The Correlation Between Diabetic Retinopathy and Serum Lipoperoxide,Nippon Ganka Gakkai Zasshi 89, 379–382.
- Hayakawa, M., and Kuzuya, F. (1990) Free Radicals and Diabetes Mellitus,Nippon Ronen Igakkai Zasshi 27, 149–154.
- Jain, S.K., McVie, R., Duett, J., and Herbst, J.J. (1989) Erythrocyte Membrane Lipid Peroxidation and Glycosylated Hemoglobin in Diabetes,Diabetes 38, 1539–1543. CrossRef
- Rajeswari, P., Natarajan, R., Nadler, J.L., and Kumar, D. (1991) Glucose Induces Lipid Peroxidation and Inactivation of Membrane Associated Ion Transport Enzymes in Human Erythrocytesin vivo andin vitro, J. Cell Physiol. 149, 100–109. CrossRef
- Gugliucci, A., Menini, T., and Stahl, A.J.C. (1994) Susceptibility to Copper-Enhanced Autoxidation of VLDL+LDL Fractions from Diabetic Patients,Biochem. Mol. Biol. Int. 32, 139–147.
- Jennings, P.E., Jones, A.F., Florkowski, C.M., Lunec, J., and Barnett, A.H. (1987) Increased Diene Conjugates in Diabetic Subjects with Microangiopathy,Diabetic Med. 4, 452–456. CrossRef
- Jain, S.K., and Levine, S.N. (1995) Elevated Lipid Peroxidation and Vitamin E Quinone Levels in Heart Ventricles of Streptozotocin-Treated Diabetic Rats,Free Rad. Biol. Med. 18, 337–341. CrossRef
- Jain, S.K., Levine, S.N., Duett, J., and Hollier, B. (1991) Reduced Vitamin E and Increased Lipofuscin Products in Erythrocytes of Diabetic Rats,Diabetes 40, 1241–1244. CrossRef
- Ghiselli, A., Laurenti, O., De Mattia, G., Maiani, G., and Ferro-Luzzi, A. (1992) Salicylate Hydroxylation as an Early Marker ofin vivo Oxidative Stress in Diabetic Patients,Free Rad. Biol. Med. 13, 621–626. CrossRef
- Young, I.S., Torney, J.J., and Trimble, E.R. (1992) The Effect of Ascorbate Supplementation on Oxidative Stress in the Streptozotocin Diabetic Rat,Free Rad. Biol. Med. 13, 41–46. CrossRef
- Jain, S.K., Levine, S.N., Duett, J., and Hollier, B. (1990) Elevated Lipid Peroxidation Levels in Red Blood Cells of Streptozotocin-Treated Diabetic Rats,Metabolism 39, 971–975. CrossRef
- Yagi, K. (1987) Lipid Peroxides and Human Disease,Chem. Phys. Lipids 45, 337–351. CrossRef
- Jain, S.K. (1989) Hyperglycemia Can Cause Membrane Lipid Peroxidation and Osmotic Fragility in Human Red Blood Cells,J. Biol. Chem. 264, 21340–21345.
- Jain, S.K., and Hochstein, P. (1980) Polymerization of Membrane Components in Aging Red Blood Cells,Biochem. Biophys. Res. Commun. 92, 247–254. CrossRef
- Jain, S.K. (1988) Evidence for Membrane Lipid Peroxidation During thein Vivo Aging of Human Erythrocytes,Biochim. Biophys. Acta 937, 205–210. CrossRef
- Jain, S.K. (1984) The Accumulation of Malonyldialdehyde, a Product of Fatty Acid Peroxidation, Can Disturb Aminophospholipid Organization in the Membrane Bilayer of Human Erythrocytes,J. Biol. Chem. 259, 3391–3394.
- Jain, S.K. (1985)In vivo Externalization of Phosphatidylserine and Phosphatidylethanolamine in the Membrane Bilayer and Hypercoagulability by the Lipid Peroxidation of Erythrocytes in Rats,J. Clin. Invest. 76, 281–286. CrossRef
- Wali, R.K., Jaffe, S., Kumar, D., Sorgente, N., and Kalra, V.K. (1987) Increased Adherence of Oxidant-Treated Human and Bovine Erythrocytes to Cultured Endothelial Cells,J. Cell. Physiol. 133, 25–36. CrossRef
- Brunauer, L.S., Moxness, M.S., and Huestis, W.H. (1994) Hydrogen Peroxide Oxidation Induces the Transfer of Phospholipids from the Membrane into the Cytosol of Human Erythrocytes,Biochemistry 33, 4527–4532. CrossRef
- Connor, J., Pak, C.C., and Schroit, A.J. (1994) Exposure of Phosphatidylserine in the Outer Leaflet of Human Red Blood Cells. Relationship to Cell Density, Cell Age and Clearance by Mononuclear Cells,J. Biol. Chem. 269, 2399–2404.
- Gisinger, C., Watanabe, J., and Colwell, J.A. (1990) Vitamin E and Platelet Eicosanoids in Diabetes Mellitus,Prostagl. Leuk. Essent. Fatty Acids 40, 169–176. CrossRef
- Pritchard, K.A. Jr., Patel, S.T., Karpen, C.W., Newman, H.A., and Panganamala, R.V. (1986) Triglyceride-Lowering Effect of Dietary Vitamin E in Streptozocin-Induced Diabetic Rats. Increased Lipoprotein Lipase Activity in Livers of Diabetic Rats Fed High Dietary Vitamin E,Diabetes 35, 278–281. CrossRef
- Aoki, Y., Yanagisawa, Y., Yazaki, K., Oguchi, H., Kiyosawa, K., and Furuta, S. (1992) Protective Effect of Vitamin E Supplementation on Increased Thermal Stability of Collagen in Diabetic Rats,Diabetologia 35, 913–916. CrossRef
- Mullarkey, C.J., Edelstein, D., and Brownlee, M. (1990) Free Radical Generation by Early Glycation Products: A Mechanism for Accelerated Atherogenesis in Diabetes,Biochem. Biophys. Res. Commun. 173, 932–939. CrossRef
- Onuma, T., Tsutsui, M., Ochiai, S., Boku, A., Tamazawa, A., and Takebe, K. (1993) Effect of Vitamin E on Plasma Lipoprotein Abnormalities in Diabetic Rats,Diab. Nutr. Metabol. 6, 135–138.
- Paolisso, G., D'Amore, A., Galzerano, D., Balbi, B., Giugliano, D. Varricchio, M., and D'Onofrio, F. (1993) Daily Vitamin E Supplements Improve Metabolic Control But Not Insulin Secretion in Elderly Type-II Diabetic Patients,Diabetes Care 16, 1433–1437. CrossRef
- The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients
Volume 31, Issue 1 , pp S87-S90
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. Department of Pediatrics, Louisiana State University Medical Center, 1501 Kings Highway, 71130, Shreveport, LA
- 2. Department of Pathology, Louisiana State University Medical Center, 1501 Kings Highway, 71130, Shreveport, LA