, Volume 31, Issue 1, pp S33–S36

Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice

  • Katrina M. Waters
  • James M. Ntambi
The Role of Fatty Acids in Gene Expression

DOI: 10.1007/BF02637047

Cite this article as:
Waters, K.M. & Ntambi, J.M. Lipids (1996) 31: S33. doi:10.1007/BF02637047


Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by dietary PUFA, as previously shown in normal mice. We saw dramatic repression of SCD1 mRNA expression, with trilinolenin at 3% and triarachidonin at 1% supplementation. We also observed significant repression of insulin-induced SCD1 mRNA upon supplementation of the noninducing starch diet with PUFA. In conclusion, our data demonstrate that PUFA negatively regulate hepatic gene expression through an insulin-independent mechanism.



stearoyl-CoA desaturase gene 1


stearoyl-CoA desaturase gene 2


polyunsaturated fatty acids


peroxisome proliferator-activated receptors

Copyright information

© AOCS Press 1996

Authors and Affiliations

  • Katrina M. Waters
    • 1
  • James M. Ntambi
    • 1
  1. 1.Department of BiochemistryThe University of Wisconsin-MadisonMadison