Immunogenetics

, Volume 44, Issue 5, pp 351–357

Allelic repertoire of the humanMHC class IMICA gene

  • Nassima Fodil
  • Laurent Laloux
  • Valérie Wanner
  • Philippe Pellet
  • Georges Hauptmann
  • Nobuhisa Mizuki
  • Hidetoshi Inoko
  • Thomas Spies
  • Ioannis Theodorou
  • Seiamak Bahram
Original Paper

DOI: 10.1007/BF02602779

Cite this article as:
Fodil, N., Laloux, L., Wanner, V. et al. Immunogenetics (1996) 44: 351. doi:10.1007/BF02602779

Abstract

The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassicalMHC class I genes. A distinct family ofMHC class I genes has been recently identified within the humanMHC class I region. TheMICA (MHC classI chain-relatedA) gene in this family is a highly divergent member of theMHC class I family and has a unique pattern of tissue expression. We have sequenced exons encoding the extracellular α1, α2, and α3 domains of theMICA gene from twentyHLA homozygous typing cell lines and four unrelated individuals. We report the identification of eleven new alleles defined by a total of twenty-two amino acid substitutions. Thus, the total number ofMICA alleles is sixteen. Interestingly, a tentative superimposition ofMICA variable residues on theHLA-A2 structure reveals a unique pattern of distribution, concentrated primarily on the outer edge of the MICA putative antigen binding cleft, apparently bordering an invariant ligand binding site.

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Nassima Fodil
    • 1
  • Laurent Laloux
    • 2
  • Valérie Wanner
    • 1
  • Philippe Pellet
    • 2
  • Georges Hauptmann
    • 1
  • Nobuhisa Mizuki
    • 3
  • Hidetoshi Inoko
    • 3
  • Thomas Spies
    • 4
  • Ioannis Theodorou
    • 2
  • Seiamak Bahram
    • 5
  1. 1.Centre de Recherche d'Immunologie et d'HématologieStrasbourg CedexFrance
  2. 2.Laboratoire d'Immunologie Cellulaire et TissulaireHôpital Pitié-SalpêtrièreParis Cedex 13France
  3. 3.Tokai University School of MedicineIsehara, KanagawaprefJapan
  4. 4.Clinical Research DivisionFred Hutchinson Cancer Research CenterSeattleUSA
  5. 5.Basel Institute for ImmunologyBaselSwitzerland

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