Clinical scoring system for hypothyroidism
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
A clinical scoring system for hypothyroidism was evaluated against an established “gold standard” (low serum thyroxine and elevated thyroid-stimulating hormone) in 52 adults in a peripheral hospital and in 53 adults in a endocrinology referral clinic. Using a score of 0 as a cutoff point, the scoring system selected patients with hypothyroidism from the referral center for further biochemical evaluation; at the same time, it excluded hypothyroidism with confidence in 42% of euthyroid subjects. In the peripheral hospital, a cutoff score of −10 selected 92% of hypothyroid subjects for further evaluation and excluded hypothyroidism in 55% of euthyroid subjects. Two cutoff points were needed because the prevalences of hypothyroidism in the two centers differed. The simple scoring system increased the pretest probability of disease by 15% in the peripheral hospital and by 19% in the referral clinic. In countries where resources are limited, this scoring system can improve the clinical evaluation of patients who have one or more symptoms of hypothyroidism and reduce the load on referral centers.
- Billewicz WZ, Chapman RS, Crooks J, Day ME, Gossage J, Wayne E, Young JA. Statistical methods applied to the diagnosis of hypothyroidism. Q J Med (NS). 1969;38:255.
- Barker DJP, Bishop JM. Computer-based screening system for patients at risk of hypothyroidism. Lancet. 1969:II;835. CrossRef
- Kanagasabapathy AS, Karunanidhi A, Koshi TS. A comparison of Thyopac-3 and T3 resin uptake for the calculation of free thyroxine index for assessing thyroid status. Indian J Med Res. 1977:66;479.
- Fletcher RH, Fletcher SW, Wagner EH, eds. Clinical epidemiology—the essentials. Baltimore: Williams and Wilkins, 1982:41–58.
- Beck JR, Shultz EK. The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med. 1986:110;13–20.
- Clinical scoring system for hypothyroidism
Journal of General Internal Medicine
Volume 4, Issue 6 , pp 490-492
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors