Insulin-like growth factor-I, interleukin-1 α and β in pancreatic cancer: role in tumor invasiveness and associated diabetes

  • D. Basso
  • M. Plebani
  • P. Fogar
  • M. P. Panozzo
  • T. Meggiato
  • M. De Paoli
  • G. Del Favero
Originals

DOI: 10.1007/BF02592575

Cite this article as:
Basso, D., Plebani, M., Fogar, P. et al. Int J Clin Lab Res (1995) 25: 40. doi:10.1007/BF02592575

Summary

We evaluated levels of insulin-like growth factor-I and interleukin-1 α and β in patients with pancreatic cancer; the role of these substances in tumor spread and in hyperglycemia was also investigated. Thirty pancreatic cancer patients (21 with hyperglycemia) were compared with others with diseases causing hyperglycemia [liver cirrhosis (14 cases, 12 with hyperglycemia), chronic pancreatitis (20 cases, 12 with hyperglycemia), type I diabetes mellitus (13 cases, all hyperglycemic)]. Insulin-like growth factor-I was significantly reduced in patients with liver cirrhosis, probably due to a reduced hepatic capacity for synthesis. It was increased in 6 of 30 pancreatic cancer patients; in these subjects it was correlated with alanine aminotransferase and C-peptide, but not with tumor diameter or the presence of metastases. Interleukin-1α and β were both elevated in pancreatic cancer patients. The former was high, while the latter was low when liver metastases were present. Neither was related to glucose or C-peptide levels. In summary, insulin-like growth factor-I levels are increased in some pancreatic cancer patients but this does not seem to favor tumor spread; however IGF-I could be involved influencing glucose homeostasis. Interleukin-1 α increased, while interleukin-1β decreased in pancreatic cancer patients with metastases, suggesting a different involvement of these two substances in pancreatic cancer spread.

Key words

Pancreatic cancer Interleukin-1 Insulin-like growth factor-I Diabetes 

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • D. Basso
    • 1
  • M. Plebani
    • 1
  • P. Fogar
    • 1
  • M. P. Panozzo
    • 1
  • T. Meggiato
    • 2
  • M. De Paoli
    • 1
  • G. Del Favero
    • 2
  1. 1.Istituto di Medicina di LaboratorioUniversity of PaduaPaduaItaly
  2. 2.Cattedra di Malattie Apparato DigerenteUniversity of PaduaPaduaItaly