International Journal of Clinical and Laboratory Research

, Volume 21, Issue 2, pp 264–266

Cholesteryl ester transfer protein in human brain

Authors

  • John J. Albers
    • Department of Medicine, Northwest Lipid Research LaboratoriesUniversity of Washington
  • John H. Tollefson
    • Department of Medicine, Northwest Lipid Research LaboratoriesUniversity of Washington
  • Gertrud Wolfbauer
    • Department of Medicine, Northwest Lipid Research LaboratoriesUniversity of Washington
  • Robert E. AlbrightJr
    • University of Cincinnati
Brief Definitive Report

DOI: 10.1007/BF02591657

Cite this article as:
Albers, J.J., Tollefson, J.H., Wolfbauer, G. et al. Int J Clin Lab Res (1992) 21: 264. doi:10.1007/BF02591657

Summary

The evidence that apolipoproteins are found in the cerebrospinal fluid and low-density lipoprotein receptor is found in the brain suggests that the brain may have an active lipid transport system. In plasma, cholesteryl ester transfer protein mediates the exchange and net transfer of cholesteryl ester and triglycerides among lipoproteins. Cholesteryl ester transfer activity was measured in the cerebrospinal fluid and plasma of ten neurologically normal subjects. Cholesteryl ester transfer activity was readily detectable in cerebrospinal fluid (7.4±13% cholesteryl ester was transferred per 20 μl), and this activity was completely abolished with specific antibody against the plasma cholesteryl ester transfer protein. The concentration of cholesteryl ester transfer activity in the cerebrospinal fluid was about 12% of that found in plasma, whereas the concentration of albumin in cerebrospinal fluid was only about 0.6% of that in plasma, suggesting direct synthesis of cholesteryl ester transfer protein within the brain. Cholesteryl ester transfer activity was found in conditioned medium from human neuroblastoma and neuroglioma cells and sheep choroid plexus. The data suggest that cholesteryl ester transfer protein is synthesized and secreted in the brain. This protein could play an important role in the transport and redistribution of lipids within the central nervous system.

Key words

Cholesteryl ester transfer proteinCerebrospinal fluid

Copyright information

© Springer-Verlag 1992