Acta diabetologia latina

, Volume 15, Issue 5, pp 303–309

Functional modifications of endocrine pancreas after internal biliary fistula (experimental research)

  • Massimo Ermini
  • Carlo Macaluso
  • Pellegrino Masiello
Article

DOI: 10.1007/BF02590754

Cite this article as:
Ermini, M., Macaluso, C. & Masiello, P. Acta diabet. lat (1978) 15: 303. doi:10.1007/BF02590754

Summary

The function of the B-insular system has been explored in dogs with total internal biliary fistula (cholecysto-jejunostomy after closure of the common bile duct), an operation which causes an increase in the number and total volume of pancreatic islets. Two groups of 10 animals each were either submitted to operation or used as controls. The endocrine function of the pancreas was explored 45–60 days after surgery by assessing basal blood glucose and serum insulin. IVGTT and i.v. tolbutamide test were performed subsequently. The results indicate that in operated animals the ability to release insulin after stimulation is increased and that the control of basal hormone secretion is fully preserved.

Key-words

Biliary fistulaEndocrine pancreasExperimental biliary fistulaInternal biliary fistula

Copyright information

© Casa Editrice «il Ponte» 1978

Authors and Affiliations

  • Massimo Ermini
    • 2
    • 1
  • Carlo Macaluso
    • 2
    • 1
  • Pellegrino Masiello
    • 2
    • 1
  1. 1.Istituto di Patologia GeneraleUniversità di PisaItaly
  2. 2.Istituto di Patologia Speciale Chirurgica e Propedeutica Clinica IUniversità degli StudiPisaItaly