Research in Experimental Medicine

, Volume 195, Issue 1, pp 1–8

Effect of prior portosystemic shunt on early hepatic hemodynamics and sinusoids following 84% hepatectomy in dogs

  • Shinichi Ueno
  • Yasuyuki Kobayashi
  • Kouichi Kurita
  • Gen Tanabe
  • Takashi Aikou
Original Papers

DOI: 10.1007/BF02576768

Cite this article as:
Ueno, S., Kobayashi, Y., Kurita, K. et al. Res. Exp. Med. (1995) 195: 1. doi:10.1007/BF02576768

Abstract

The effects of a prior portosystemic shunt (PSS) on the hepatic hemodynamics and sinusoids shortly after an 84% hepatectomy (Hx) were investigated in dogs. Fifteen mongrel dogs were divided into three groups, a 70% Hx group (n=5), an 84% Hx group (n=5) and an 84% Hx+PSS group (n=5). In the last group, a shunt was inserted between the splenic and femoral veins prior to the hepatectomy. The systemic and hepatic hemodynamics were measured, before and 180 min after the hepatectomy, and the remaining liver tissue was then examined immuno-histochemically by light microscopy using the thrombomodulin (TM) staining method. The postoperative portal vein pressure and the vascular resistance were significantly lower in the PSS group than in the 84% non-PSS group. The total postoperative hepatic blood flow was higher in the 84% non-PSS group than in the other two groups. Immunohistochemical observation after TM staining indicated that the sinusoidal endothelial cells in the 84% non-PSS group were markedly damaged 3 h after surgery. We conclude that a prior PSS improves the hepatic hemodynamics and is beneficial to the sinusoids within the first few hours of an 84% hepatectomy in dogs.

Key words

major hepatectomyHepatic hemodynamicsSinusoidal endothelial cellsPortosystemic shuntThrombomodulin

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Shinichi Ueno
    • 1
  • Yasuyuki Kobayashi
    • 1
  • Kouichi Kurita
    • 1
  • Gen Tanabe
    • 1
  • Takashi Aikou
    • 1
  1. 1.First Department of SurgeryKagoshima University School of MedicineKagoshimaJapan