Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
- Cite this article as:
- Bloomston, M., Zervos, E.E. & Rosemurgy, A.S. Annals of Surgical Oncology (2002) 9: 668. doi:10.1007/BF02574483
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Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in a variety of malignancies. Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. Inhibition of MMPs has shown great promise with synthetic inhibitors, such as BB-94, as tumorostatic agents in preclinical models, particularly when these are combined with gemcitabine. These findings have led to several clinical trials using the MMP inhibitors Marimastat and BAY 12-9566. Herein, we discuss the roles of MMPs and their inhibition in pancreatic cancer.