Annals of Surgical Oncology

, Volume 9, Issue 4, pp 333–339

Intraoperative touch preparation for sentinel lymph node biopsy: A 4-year experience

Authors

    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • Soheila Korourian
    • Department of Pathology
  • Isabel T. Rubio
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • Anita T. Johnson
    • Fashion Footwear Association of New York/Virginia Clinton Kelley Research Fellowship
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • Anne T. Mancino
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • Nicole Massol
    • Department of Pathology
  • LaNette F. Smith
    • Fashion Footwear Association of New York/Virginia Clinton Kelley Research Fellowship
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • Kent C. Westbrook
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
  • V. Suzanne Klimberg
    • Department of Veterans Affairs, Central Arkansas Veterans Healthcare SystemUniversity of Arkansas for Medical Sciences, Arkansas Cancer Research Center
    • Department of Surgery
    • Department of Pathology
Original Articles

DOI: 10.1007/BF02573867

Cite this article as:
Henry-Tillman, R.S., Korourian, S., Rubio, I.T. et al. Annals of Surgical Oncology (2002) 9: 333. doi:10.1007/BF02573867

Abstract

Background

The optimal technique for intraoperative pathologic examination of sentinel lymph nodes (SLNs) is still controversial. Recent small series report sensitivity between 60% and 100% for various techniques. The aim of this study was to evaluate our long-term experience with touch preparation cytology (TPC) and frozen section (FS) in the intraoperative examination of SLNs for breast cancer.

Methods

A total of 247 patients with operable breast cancer underwent an SLN biopsy for staging of the axilla. The SLN was identified by99mTc-labeled sulfur colloid unfiltered dye, blue dye, or both and dissected, and then intraoperative TPC or FS and permanent section, or both, were performed.

Results

A total of 479 SLNs were submitted for TPC and permanent hematoxylin and eosin. A total of 68 SLNs were positive by hematoxylin and eosin; 65 SLNs were positive by TPC, with a false-negative rate of 5.8%. The sensitivity for TPC was 94.2%, with a false-positive rate of 0.2%. A total of 165 SLNs were submitted for FS, with a sensitivity of 85.7% and a specificity of 98.6%. The false-positive rate was 1.4%, with a false-negative rate of 15.8%.

Conclusions

In a large series, TPC is as accurate as FS but is simpler and faster in the detection of intraoperative metastasis in SLNs for breast cancer.

Key Words

Sentinel lymph nodeBreast cancerTouch preparation cytologyFrozen sectionAccuracy

Copyright information

© The Society of Surgical Oncology, Inc 2002