Second primary tumours in hereditary- and nonhereditary retinoblastoma patients treated with megavoltage external beam irradiation
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The purpose of this retrospective study is to investigate the influence of 45 Gy megavoltage external beam radiotherapy on the occurrence of second primary tumours in hereditary- and non-hereditary retinoblastoma patients. Eighty-seven hereditary and 19 nonhereditary patients were irradiated for retinoblastoma. The follow-up of the hereditary patients ranged from 4–23 years (mean 12.4 years), of the non-hereditary patients from 6–23 years (mean 12 years). In the hereditary group 4 patients developed a second primary tumour (2 rhabdomyosarcoma, 1 osteosarcoma, 1 malignant histiocytoma), and 5 patients developed a pineoblastoma. Three second primary tumours were situated inside the radiation field. The latency period ranged from 1.5 to 18 years (mean 4.8 years). None of the non-hereditary patients developed a second primary tumour. The actuarially calculated probability of being free from second primary tumours was 96.9% at 10 years and 89.4% at 20 years (pineoblastoma excluded). The survival was 91.2% at 10 years and 84.2% at 20 years (pineoblastoma excluded). From this study it is suggested that external beam irradiation has a potentiating effect in patients, with the genetic predispopsition for retinoblastoma and who are more susceptible to second primary malignancies.
- Draper GJ, Sanders BM, Kingston JE, Second primary neoplasms in patients with retinoblastoma. Brit. J. Cancer, 53: 661–671 1986.
- Schipper J, Retinoblastoma, a medical and experimental study. Thesis 1980, Utrecht, The Netherlands.
- Schipper J, An acurate and simple method for megavoltage radiation therapy of retinoblastoma. Radiother Oncol 1: 31–41 1983.
- Roarty JD, Mc Lean IW, Zimmerman LE, Incidence of second neoplasms in patients with bilateral retinoblastoma. Ophthalmology 95: 1583–1587, 1988.
- Jacobiec FA, Tso MO, Zimmerman LE, Danis P. Retinoblastoma and intracranial malignancy. Cancer 39, 2048–2058 (1977). CrossRef
- Forrest AW, Tumors following radiation about the eye. Trans Arn Acad Ophthalmol Otolaryngol 65: 694, 1961.
- Soloway HB, Radiation induced neoplasms following curative therapy for retinoblastoma. Cancer 19: 1984, 1966.
- Sagerman RH, Cassady R, Tretter P, Ellsworth RM, Radiation induced neoplasia following external beam therapy for children with retinoblastoma. Am J Roentgenol Radium Ther Nucl Med 105: 529–535, 1969.
- Schipper J, Alberti W, Letter to editor, Ophthalmology 92: 60A-62A, 1985.
- Meadows AT, Strong LC, Li FP, D'Angio GJ, Schweisguth O, Freeman AI, Jenkin RDT, Morris-Jones P, Nesbit ME, Bone sarcomas as a second malignant neoplasm in children: Influence of radiation and genetic predisposition. Cancer 46: 2603–2606, 1980. CrossRef
- Tucker MA, D'Angio GJ, Boice JD, Strong LC, Li FP, Stovall M, Stone J, Green DM, Limbardi F, Newton W, Hoover RN, Fraumeni JF; Bone sarcomas linked to radiotherapy and chemcitherapy in children. N Engl J Med 317: 588–593, 1987. CrossRef
- Abramson DH, Ellsworth RM, Kitrhin FD, Tung G, Second nonocular tumors in retinoblastoma survivous; Are they radiation-induced?. Ophthalmology, 91: 1351–1355, 1984.
- Huvos AG, Woodard HQ, Heilweil M, Postirradiation malignant fibrous histiocytoma of bone. Am J Surg Pathol 10: 9–18, 1985.
- Schwarz MB, Burgess LPA, Fee WE, Donaldson SS, Postirradiation sarcoma in retinoblastomaa Arch Otolaryngol Head Neck Surg 114: 640–644, 1988.
- Eng C, Li FP, Abramson DH, Ellsworth RM, Wong L, Goldman MB, Seddon J, Tarbell N, Boice JD. Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst 85: 1121–8, 1993. CrossRef
- Abramson DH, Ronner HJ; Ellsworth RM, Second tumors in nonirradiated bilateral retinoblastoma. Am J Ophthal 87: 624–627, 1979
- Alberti W, Havers W, De Sutter E, Stuschke M, Incidence and analysis of second non-ocular malignancies in retinoblastoma patients. In: VI Meeting of the International Society of Genetic Eye Disease and IIIrd International Symposium on Retinoblastoma. p120; The Netherlands Ophthalmic Research Institute, Amsterdam, 1986.
- Wang Y, Kateley-Kohler S, Maher VM, Mc Cormick JJ, 60C0 radiation-induced transformation to anchorage independence of fibroblasts from normal persons and patients with inherited predisposition to retinoblastoma. Carcinogenesis 7: 1927–1929, 1985. CrossRef
- Friend SH, Bernards R, Rogelj S et al. A human DNA segment with properities of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643–46, 1985 CrossRef
- Desjardins L, Haye C, Sehlienger P, Laurent M, Zucker JM, Bouguila H, Second non-ocular tumours in survivors of bilateral retinoblastoma, A 30-year follow-up. Ophthalmic Paediatrics and Genetcs? 12; 3: 145–148, 1991.
- Lueder GT, Judisch GF, O'Gorman ThW, Second nonocular tumors in survivors of heritable retinoblastoma. Arch Ophthalmol 104: 372–373; 1986.
- DerKinderen DJ, Koten JW, Nagelkerke NJD, Tan KEWP, Beemer FA, Den Otter W. Nonocular cancer in gatients with hereditary retinoblastoma and their relatives. Int J Cancer 41: 499–504 (1988). CrossRef
- Second primary tumours in hereditary- and nonhereditary retinoblastoma patients treated with megavoltage external beam irradiation
Volume 93, Issue 4 , pp 337-344
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- megavoltage external beam radiotherapy
- second primary tumours
- Industry Sectors
- Author Affiliations
- 1. Department of Ophthalmology, Free University Hospital, Amsterdam, The Netherlands
- 3. Department of Radio-Oncology, University Hospital Utrecht, The Netherlands
- 4. Department of Ophthalmology, University Hospital Utrecht, The Netherlands