Calcified Tissue International

, Volume 49, Issue 2, pp 71–76

Prevention of corticosteroid-induced osteoporosis with salmon calcitonin in sarcoid patients

  • Lidia Montemurro
  • Gianfranco Schiraldi
  • Patricia Fraioli
  • Gianpiero Tosi
  • Angelo Riboldi
  • Gianfranco Rizzato
Clinical Investigations

DOI: 10.1007/BF02565124

Cite this article as:
Montemurro, L., Schiraldi, G., Fraioli, P. et al. Calcif Tissue Int (1991) 49: 71. doi:10.1007/BF02565124

Summary

The aim of this study was to evaluate the usefulness of salmon calcitonin (sCT) in preventing corticosteroid-induced osteoporosis. Three groups of patients with sarcoidosis requiring long-term steroid therapy were followed for 2 years with yearly evaluations of vertebral cancellous mineral content (VCMC) by quantitative computed tomography. The first group (n=18) was treated with intramuscular (i.m.) sCT for the 2-year study period; the second (n=11) with i.m. sCT for the first 4 months and then with sCT nasal spray for 20 months; the third (n=35) received no sCT. We observed a large mineral loss in the third group but a very slight drop of VCMC in the two groups receiving sCT. SCT nasal spray was better tolerated and as effective as i.m. injections. The action of sCT appeared extremely useful, especially in the first year of steroid therapy when corticosteroid-induced mineral loss was maximal. We conclude that sCT nasal spray is a good tool for preventing corticosteroid-induced osteoporosis.

Key words

PrednisoneCorticosteroid-induced osteoporosisCalcitoninQuantitative computed tomographySarcoidosis

Copyright information

© Springer-Verlag New York Inc 1991

Authors and Affiliations

  • Lidia Montemurro
    • 1
    • 2
  • Gianfranco Schiraldi
    • 1
    • 2
  • Patricia Fraioli
    • 1
    • 2
  • Gianpiero Tosi
    • 1
    • 2
  • Angelo Riboldi
    • 1
    • 2
  • Gianfranco Rizzato
    • 1
    • 2
  1. 1.Sarcoidosis ClinicMilanItaly
  2. 2.Department of Medical PhysicsNiguarda HospitalMilanItaly