Calcified Tissue International

, Volume 46, Issue 5, pp 305–308

Malabsorption of calcium in corticosteroid-induced osteoporosis

  • H. A. Morris
  • A. G. Need
  • P. D. O'Loughlin
  • M. Horowitz
  • A. Bridges
  • B. E. C. Nordin
Clinical Investigations

DOI: 10.1007/BF02563820

Cite this article as:
Morris, H.A., Need, A.G., O'Loughlin, P.D. et al. Calcif Tissue Int (1990) 46: 305. doi:10.1007/BF02563820

Summary

We have examined the relation between radiocalcium absorption and serum 1,25-dihydroxy-vitamin D [1,25(OH)2D3] levels in a set of 60 postmenopausal women on corticosteroid therapy (29 with and 31 without vertebral compression fractures) and compared these results with those from 31 normal postmenopausal women age-matched with the “normal” corticosteroid-treated women. Radiocalcium absorption was a function of serum 1,25(OH)2D3 in both corticosteroid-treated groups and in the set as a whole, but the impaired calcium absorption in the corticosteroid-treated patients with osteoporosis was not accounted for by their slightly reduced serum 1,25(OH)2D3 levels. This apparent resistance to the intestinal action of 1,25(OH)2D3 was quantified by a Z score which expresses, in standard deviation units, the difference between the measured calcium absorption and that predicted from the 1,25(OH)2D3 level. The Z score was significantly reduced in the osteoporotic group. Vertebral mineral density (VMD) was measured by quantitative computed tomography in 43 of the corticosteroid-treated cases and in all the normal postmenopausal women; analysis by VMD yielded similar conclusions.

Key words

CorticosteroidsOsteoporosisCalcium absorptionSerum 1,25(OH)2D3

Copyright information

© Springer-Verlag New York Inc 1990

Authors and Affiliations

  • H. A. Morris
    • 1
  • A. G. Need
    • 1
  • P. D. O'Loughlin
    • 1
  • M. Horowitz
    • 3
  • A. Bridges
    • 4
  • B. E. C. Nordin
    • 1
    • 2
  1. 1.Division of Clinical ChemistryInstitute of Medical and Veterinary Science
  2. 2.Department of PathologyUniversity of AdelaideAdelaideAustralia
  3. 3.Department of MedicineRoyal Adelaide HospitalAdelaideAustralia
  4. 4.Department of RadiologyRoyal Adelaide HospitalAdelaideAustralia