Lipids

, Volume 34, Supplement 1, pp S187–S189

n-3 fatty acids in the prevention of cardiac arrhythmias

  • Alexander Leaf
  • Jing X. Kang
  • Yong-Fu Xiao
  • George E. Billman
Cardiovascular System

DOI: 10.1007/BF02562284

Cite this article as:
Leaf, A., Kang, J.X., Xiao, YF. et al. Lipids (1999) 34: S187. doi:10.1007/BF02562284

Abstract

In animals and probably in humans n-3 polyunsaturated fatty acids (PUFA) are antiarrhythmic. A report follows on the recent studies of the antiarrhythmic actions of PUFA. The PUFA stabilize the electrical activity of isolated cardiac myocytes by inhibiting sarcolemmal ion channels, so that a stronger electrical stimulus is required to elicit an action potential and the relative refractory period is markedly prolonged. This appears at present to be the probable major antiarrhythmic mechanism of PUFA.

Abbreviations

PUFA

polyunsaturated fatty acid

VF

ventricular fibrillation

Copyright information

© AOCS Press 1999

Authors and Affiliations

  • Alexander Leaf
    • 1
  • Jing X. Kang
    • 1
  • Yong-Fu Xiao
    • 2
  • George E. Billman
    • 3
  1. 1.Department of MedicineMassachusetts General HospitalUSA
  2. 2.Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical SchoolBoston
  3. 3.Department of PhysiologyThe Ohio State UniversityColumbus