Lipids

, Volume 34, Supplement 1, pp S91–S92

Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat

Lipids And Insulin Resistance

DOI: 10.1007/BF02562242

Cite this article as:
McLennan, P.L. & Raederstorff, D. Lipids (1999) 34: S91. doi:10.1007/BF02562242

Conclusions

The changes in fatty acid incorporation into myocardial membranes that occurred with acute diabetes in this study were indicative of depressed PUFA desaturation. However this was largely confined to the long-chain n-3 PUFA, DHA. Anti-arrhythmic efficets of n-3 PUFA diets were associated with elevated DHA levels. It is conclused that perturbed PUFA metabolism in diabetes puts myocardial n-3 PUFA status at high risk which may have important implications for heart function and that this may be prevented by low-level supplementation with purified DHA.

Abbreviations

DHA

docosahexaenoic acid

EPA

licosapentaenoic acid

OO

olive oil

PUFA

polyunsaturated fatty acid

Copyright information

© AOCS Press 1999

Authors and Affiliations

  1. 1.CSIRO Division of Human NutritionAdelaideAustralia
  2. 2.Smart Foods Centre, Department of Biomedical ScienceUniversity of WollongongAustralia
  3. 3.Hoffmann-La RocheBaselSwitzerland