Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
The changes in fatty acid incorporation into myocardial membranes that occurred with acute diabetes in this study were indicative of depressed PUFA desaturation. However this was largely confined to the long-chain n-3 PUFA, DHA. Anti-arrhythmic efficets of n-3 PUFA diets were associated with elevated DHA levels. It is conclused that perturbed PUFA metabolism in diabetes puts myocardial n-3 PUFA status at high risk which may have important implications for heart function and that this may be prevented by low-level supplementation with purified DHA.
- Fein, F.S. (1996) Clinical Manifestations of Diabetic Cardiomyopathy, in Chatham, J.C. Forder, J.R., and McNeill, J.H. (eds.)The Heart in Diabetes. (Kluwer, Dortrect, Netherlands).Developments in Cardiovascular Med. 185, 1–22.
- Daviglus, M.L., Stamler, J., Orencia, A.J.,et al. (1997) Fish Consumption and the 30-year Risk of Fatal Myocardial Infarction,N. Eng. J. Med. 336, 1046–1053. CrossRef
- Faas, F.H., and Carter, W.J. (1980) Altered Fatty Acid Desaturation and Microsomal Fatty Acid Composition in the Streptozotocin Diabetic Rat,Lipids 15, 953–961. CrossRef
- McLennan, P.L. (1992) Relative Effects of Dietary Saturated Monounsaturated and Polyunsaturated Fatty Acids on Cardiac Arrhythmias in the Rat.Am. J. Clin. Nutr. 57, 207–212.
- Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat
Volume 34, Issue 1 Supplement, pp S91-S92
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors