, Volume 34, Supplement 1, pp S91–S92

Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat

Lipids And Insulin Resistance

DOI: 10.1007/BF02562242

Cite this article as:
McLennan, P.L. & Raederstorff, D. Lipids (1999) 34: S91. doi:10.1007/BF02562242


The changes in fatty acid incorporation into myocardial membranes that occurred with acute diabetes in this study were indicative of depressed PUFA desaturation. However this was largely confined to the long-chain n-3 PUFA, DHA. Anti-arrhythmic efficets of n-3 PUFA diets were associated with elevated DHA levels. It is conclused that perturbed PUFA metabolism in diabetes puts myocardial n-3 PUFA status at high risk which may have important implications for heart function and that this may be prevented by low-level supplementation with purified DHA.



docosahexaenoic acid


licosapentaenoic acid


olive oil


polyunsaturated fatty acid

Copyright information

© AOCS Press 1999

Authors and Affiliations

  1. 1.CSIRO Division of Human NutritionAdelaideAustralia
  2. 2.Smart Foods Centre, Department of Biomedical ScienceUniversity of WollongongAustralia
  3. 3.Hoffmann-La RocheBaselSwitzerland