Infection

, Volume 27, Issue 2, pp 92–96

Seroprevalence and disease association of antineutrophil cytoplasmic autoantibodies and antigens in HIV infection

  • O. A. Cornely
  • S. Hauschild
  • C. Weise
  • E. Csernok
  • W. L. Gross
  • B. Salzberger
  • G. Fätkenheuer
  • V. Diehl
  • M. Schrappe
Clinical and Epidemiological Studies Originalia

DOI: 10.1007/BF02560504

Cite this article as:
Cornely, O.A., Hauschild, S., Weise, C. et al. Infection (1999) 27: 92. doi:10.1007/BF02560504

Summary

This prospective study was designed to determine the role of antineutrophil cytoplasmic autoantibodies (ANCA) in HIV-infected patients. Immunofluorescence tests (IFT) and enzyme-linked immunosorbent assays (ELISA) were applied to sera of 199 consecutive outpatients. In the IFT 20% were positive. An atypical ANCA pattern was demonstrated in 67% of these, 33% revealed a perinuclear staining (pANCA). Specific ELISA revealed proteinase 3 (n=2), myeloperoxidase (n=1), lysozyme (n=2), lactoferrin (n=1), cathepsin G (n=1), and human leukocyte elastase (HLE, n=6). The target antigen remained unidentified in 26 patients. Perinuclear ANCA-positive patients showed atypical antigens in eight of 13 cases; all six patients with anti-HLE revealed a pANCA pattern. The antigens of atypical ANCA-positive patients remained unidentified in 21 of 26 (81%) cases. No signs of vasculitis were present in the ANCA-positive patients. ANCA are frequently found in the sera of HIV-positive patients. They bind to a variety of antigens. No correlation was found between ANCA positivity and autoimmune or opportunistic diseases.

Copyright information

© MMV Medien & Medizin VerlagsGmbH 1999

Authors and Affiliations

  • O. A. Cornely
    • 1
  • S. Hauschild
    • 3
  • C. Weise
    • 1
  • E. Csernok
    • 3
  • W. L. Gross
    • 3
  • B. Salzberger
    • 1
  • G. Fätkenheuer
    • 1
  • V. Diehl
    • 1
  • M. Schrappe
    • 2
  1. 1.Klinik I für Innere MedizinUniversitätskliniken KölnKöln
  2. 2.Qualitäts-managementUniversitätskliniken KölnKöln
  3. 3.Klinik für RheumatologieUniversität Lübeck, and Rheumaklinik Bad Bramstedt GmbHBad BramstedtGermany