Annals of Surgical Oncology

, Volume 9, Issue 9, pp 912–919

Breast-conservation therapy in early-stage breast cancer patients with a positive family history

  • Georges Vlastos
  • Nadeem Q. Mirza
  • Funda Meric
  • Kelly K. Hunt
  • Attiqa N. Mirza
  • Lisa A. Newman
  • Frederick C. Ames
  • Henry M. Kuerer
  • Merrick I. Ross
  • Barry Feig
  • Gildy Babiera
  • Thomas A. Buchholz
  • Gabriel N. Hortobagyi
  • S. Eva Singletary
Original Articles

DOI: 10.1007/BF02557530

Cite this article as:
Vlastos, G., Mirza, N.Q., Meric, F. et al. Annals of Surgical Oncology (2002) 9: 912. doi:10.1007/BF02557530
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Abstract

Background

Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer.

Methods

Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0–II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method.

Results

The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21–88), with a median follow-up time of 8.8 years (range, .25–29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH.

Conclusions

Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.

Copyright information

© The Society of Surgical Oncology, Inc 2002

Authors and Affiliations

  • Georges Vlastos
    • 1
  • Nadeem Q. Mirza
    • 2
  • Funda Meric
    • 2
  • Kelly K. Hunt
    • 2
  • Attiqa N. Mirza
    • 2
  • Lisa A. Newman
    • 5
  • Frederick C. Ames
    • 2
  • Henry M. Kuerer
    • 2
  • Merrick I. Ross
    • 2
  • Barry Feig
    • 2
  • Gildy Babiera
    • 2
  • Thomas A. Buchholz
    • 3
  • Gabriel N. Hortobagyi
    • 4
  • S. Eva Singletary
    • 2
  1. 1.Department of Obstetrics and GynecologySenology Geneva UniversityGenevaSwitzerland
  2. 2.Departments of Surgical OncologyThe University of Texas M.D. Anderson Cancer CenterHouston
  3. 3.Radiation OncologyThe University of Texas M.D. Anderson Cancer CenterHouston
  4. 4.Breast Medical OncologyThe University of Texas M.D. Anderson Cancer CenterHouston
  5. 5.Karmanos Cancer CenterDetroit
  6. 6.Department of Surgical OncologyThe University of Texas M.D. Anderson Cancer CenterHouston