, Volume 28, Issue 2, pp 211-214

Effect of digital rectal examination on plasma prostate-specific antigen (PSA)

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Presented are results of determination of plasma PSA before, 1 and 24 hours and 3 weeks after digital rectal examination (DRE) in 130 patients with prostatic adenoma (BPH). Mean pre-examination PSA level was 8.5 ng/ml (max. 27.0 ng/ml, min 0.3 ng/ml, SD=6.2). PSA rose at 1 and 24 hr post-DRE: 9.4 ng/ml (max. 28.9 ng/ml, min 0.5 ng/ml, SD=6.7) and 10.7 ng/ml (max. 28.0 ng/ml, min 0.5 ng/ml, SD=7.9), respectively.

Conclusion: in patients with prostatic adenoma DRE is followed by a rise in plasma PSA, which returns almost to baseline values by 3 weeks.