Pharmacology and Toxicology

Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 5, pp 498-499

First online:

Antimotion effect of nooglutyl and its neuronal mechanism

  • V. V. YasnetsovAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia
  • , V. A. PravdivtsevAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia
  • , V. M. PopovAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia
  • , T. A. VoroninaAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia
  • , N. M. KiselevaAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia
  • , S. B. KozlovAffiliated withIndustrial Research Center Gidrobios, Ministry of Health of Russia

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Abstract

Experiments on rats demonstrate that nooglutyl exhibits pronounced vestibular-protective properties and by its antimotion activity does not rank below classic vestibular protectors, such as scopolamine and diprazine. Electrophysiological experiments on cats show that nooglutyl alters spontaneous activity in 80% of cortical neurons (somatosensory zone I and area 5 of the parietal association cortex) and considerably weakens effects caused by motion sickness: activation of single unit activity of somatosensory zone I and inhibition of neuron responses to somatic stimulation. This property of the preparation is believed to form the basis of its antimotion effect.

Key words

nooglutyl motion sickness cortical neurons