Lipids

, Volume 30, Issue 2, pp 163–167

Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats

Authors

  • Maria Fiordaliso
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
  • Nadine Kok
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
  • Jean-Pierre Desager
    • Laboratoire de Pharmacothérapie, Faculté de MédecineUniversité Catholique de Louvain
  • Fabienne Goethals
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
  • Dominique Deboyser
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
  • Marcel Roberfroid
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
  • Nathalie Delzenne
    • Unité de Biochimie Toxicologique et Cancérologique, Département des Sciences PharmaceutiquesUniversité Catholique de Louvain
Article

DOI: 10.1007/BF02538270

Cite this article as:
Fiordaliso, M., Kok, N., Desager, J. et al. Lipids (1995) 30: 163. doi:10.1007/BF02538270

Abstract

The present study was aimed at answering the question why feeding rats an oligofructose (OFS) supplemented diet could cause a significant reduction in plasma lipid levels. Daily administration of a 10% (w/w) OFS-containing diet to normolipidemic male rats resulted in a decrease in plasma triglycerides, phospholipids and cholesterol. The triglyceride-lowering effect was observed after one week and lasted for at least 16 wk and was associated with a reduction in plasma very low density lipoproteins, indicating that the hypolipidemic effect of OFS may be due to changes in liver lipid metabolism. We therefore tested whether OFS feeding modified the capacity of the liver to synthesize triglycerides from free fatty acids. Hepatocytes isolated from livers of control and OFS-fed rats were incubated in the presence of [1-14C]palmitate, and both intracellular and extracellular [14C]triglyceride formation were quantified. We found that chronic feeding of an OFS-supplemented diet to rats significantly reduced the capacity of isolated hepatocytes to synthesize triglycerides from palmitate. The results suggest that, like other soluble dietary fibers, OFS significantly alters liver lipid metabolism, resulting over time in a significant reduction in plasma triglyceride, phospholipid and cholesterol levels.

Abbreviations

ANOVA

analysis of variance

BSA

bovine serum albumin

HDL

high-density lipoprotein

IDL

intermediate density lipoprotein

LDL

low-density lipoprotein

NDO

nondigestible oligosaccharide

OFS

oligofructose

SCFA

short-chain fatty acids

SEM

standard error of the mean

VLDL

very low density lipoprotein

Copyright information

© American Oil Chemists’ Society 1995