Diets rich in lean beef increase arachidonic acid and long-chain ω3 polyunsaturated fatty acid levels in plasma phospholipids
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Diets rich in meat are claimed to contribute to the high tissue arachidonic acid (20∶4ω6) content in people in Westernized societies, but there are very few direct data to substantiate this assertion. Because meat contains a variety of long-chain polyunsaturated fatty acids (PUFA) that are susceptible to oxidation, we initially examined the effect of cooking on the long-chain PUFA content of beef, and then determined the effect of ingestion of lean beef on the concentration of long-chain PUFA in plasma phospholipids (PL). First, we examined the effect of grilling (5–15 min) and frying (10 min) different cuts of fat-trimmed lean beef on the long-chain PUFA content. Second, we investigated the effect of including 500 g lean beef daily (raw weight) for 4 wk on the fatty acid content and composition of plasma PL in 33 healthy volunteers. This study was part of a larger trial investigating the effect of lean beef on plasma cholesterol levels. In the first two weeks, the subjects ate a very low-fat diet (10% energy) followed by an increase in the dietary fat by 10% each week for the next 2 wk. The added fat consisted of beef fat, or olive oil (as the oil or a margarine) or safflower oil (as the oil or a margarine). This quantity of beef provided 60, 230, 125, 140 and 20 mg/d, respectively, of eicosatrienoic acid (20∶3ω6), 20∶4ω6, eicosapentaenoic acid (20∶5ω3), docosapentaenoic acid (22∶5ω3) and docosahexaenoic acid (22∶6ω3). Grilling for 10–15 min, but not frying, of the fat-trimmed lean beef resulted in 20–30% losses of the 20 and 22 carbon PUFA. The consumption of the lean beef during the first two-week period, when there was a very low level of dietary fat, was associated with significant increases in the proportion and concentration of 20∶3ω6, 20∶4ω6, 20∶5ω3 and 22∶5ω3 in the plasma PL and a significant decrease in the proportion and content of 18∶2ω6. The addition of beef fat or olive oil to the diets containing lean beef did not alter the plasma PL fatty acid profile compared with the very low-fat diet, whereas the addition of safflower oil maintained the significant increases in 20∶4ω6 and 22∶5ω3 but led to decreases in 18∶3ω3 and 20∶5ω3 compared with the very lowfat diet. The results showed that diets rich in lean beef increased the 20∶3ω6, 20∶4ω6 and the long-chain ω3 PUFA levels in the plasma PL. A high level of linoleic acid in diets rich in lean beef prevented the rise in the plasma level of 20∶3ω6 and 20∶5ω3, two fatty acids known to antagonize the effects of 20∶4ω6 on platelet aggregation.
- James, P., Norum, K., and Rosenberg, I. (1992)Nutr. Rev. 50, 68–70. CrossRef
- Budowski, P., and Crawford, M.A. (1985)Proc. Nutr. Soc. 44, 221–229. CrossRef
- Dolecek, T.A. (1992)Proc. Soc. Exp. Biol. Med. 200, 177–182.
- Baghurst, K.I., Crawford, D.A., Worsley, D.A., and Record, S.J. (1988)Med. J. Aust. 149, 13–20.
- Holman, R.T. (1964)Fed. Proc. 23, 1062–1067.
- Sinclair, A.J., and O'Dea, K. (1990)Reducing Fat in Meat Animals (Wood, G. and Fisher, G., eds.) pp. 1–47, Elsevier Applied Science Publishers, New York.
- Mohrhauer, H., and Holman, R.T. (1963)J. Lipid Res. 4, 151–159.
- Sinclair, A.J. (1975)Lipids 10, 175–184. CrossRef
- Seyberth, H.W., Oetz, O., Kennedy, T., Sweetman, B.J., Danon, A., Frolich, J.C., Heimberg, M., and Oates, J.A. (1975)Clin. Pharmacol. Ther. 18, 521–529.
- Sinclair, A.J., O'Dea, K., Dunstan, G., Ireland, P.D., and Niall, M. (1987)Lipids 22, 523–529.
- Phinney, S.D., Odin, R.S., Johnson, S.B., and Holman, R.T. (1990)Am. J. Clin. Nutr. 51, 385–392.
- Garg, A., Bonanome, A., Grundy, S.M., Zhang, Z.J., and Unger, R.H. (1988)N. Eng. J. Med. 319, 829–834. CrossRef
- Berner, L.A. (1993)J. Nutr. 123, 1175–1184.
- Kinsella, J.E., Lokesh, B., and Stone, R.A. (1990)Am. J. Clin. Nutr. 52, 1–28.
- O'Dea, K., Traianedes, K., Chisholm, K., Leyden, H., and Sinclair, A.J. (1990)Am. J. Clin. Nutr. 52, 491–494.
- Morgan, S., O'Dea, K., and Sinclair, A.J. (1993)J. Am. Dietet. Assoc. 93, 644–648. CrossRef
- Sinclair, A.J., and O'Dea, K. (1987)Food Technol. Aust. 39, 228–231.
- U.S. Department of Agriculture (1986)Composition of Foods. Agriculture Handbook, No. 8–13 U.S. Government Printing Office, Washington, D.C.
- Marmer, W.N., Maxwell, R.J., and Williams, J.E. (1984)J. Anim. Sci. 59, 109–123.
- Terrell, R.N., Suess, G.G., Cassens, R.G., and Bray R.W. (1968)J. Food Sci. 33, 562–565. CrossRef
- Anderson, D.B., Breedenstein, B.B., Kaufinan, R.G., Cassens, R.G., and Bray, R.W. (1971)J. Food Technol. 6, 141–152. CrossRef
- Janicki, L.J., and Appledorf, H. (1974)J. Food Sci. 39, 715–717.
- Dratz, E.A., and Dees, A.J. (1986) inHealth Effects of Polyunsaturated Fatty Acids in Seafoods (Lands, W.E.M., ed.) pp. 319–351, Academic Press, New York.
- Hodge, J., Sanders, K., and Sinclair, A.J. (1993)Lipids 28, 525–531.
- Lasserre, M., Mendy, F., Spielman, D., and Jacotot, B. (1985)Lipids 20, 227–233. CrossRef
- Lands, W.E.M. (1991)Ann. Rev. Nutr. 11, 41–60. CrossRef
- Willis, A.L., and Smith, D.L. (1989) inNew Protective Roles for Selected Nutrients (Spiller, G.A., and Scala, J., eds.) pp. 40–108, Alan R. Liss, New York.
- von Schacky, C., Fischer, S., and Weber, P.C. (1985)J. Clin. Invest. 76, 1626–1631. CrossRef
- Knapp, H.R., Reilly, I.A.G., Alessandrini, P. and FitzGerald, G.A. (1986)N. Engl. J. Med. 314, 937–942. CrossRef
- Holman, R.T., Johnson, S.B., and hatch, T.F. (1982)Am. J., Clin. Nutr. 35, 617–623.
- Holman, R.T. (1993) inEssential Fatty Acids and Eicosanoids: Invited Papers from the Third International Congress (Sinclair, A.J., and Gibson, R.A., eds.) pp. 3–17, AOCS Press, Champaign.
- Diets rich in lean beef increase arachidonic acid and long-chain ω3 polyunsaturated fatty acid levels in plasma phospholipids
Volume 29, Issue 5 , pp 337-343
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- 1. Department of Medical Laboratory Science, Royal Melbourne Institute of Technology, 3001, Melbourne, Victoria, Australia
- 2. Deakin Institute of Human Nutrition, Deakin University, 3217, Geelong, Victoria, Autralia
- 3. The Hormel Institute, University of Minnesota, 55912, Austin, Minnesota, Australia