Oxidative susceptibility of low density lipoprotein from rabbits fed atherogenic diets containing coconut, palm, or soybean oils
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The oxidative susceptibilities of low density lipoproteins (LDL) isolated from rabbits fed high-fat atherogenic diets containing coconut, palm, or soybean oils were investigated. New Zealand white rabbits were fed atherogenic semisynthetic diets containing 0.5% cholesterol and either (i) 13% coconut oil and 2% corn oil (CNO), (ii) 15% refined, bleached, and deodorized palm olein (RBDPO), (iii) 15% crude palm olein (CPO), (iv) 15% soybean oil (SO), or (v) 15% refined, bleached, and deodorized palm olein without cholesterol supplementation [RBDPO(wc)], for a period of twelve weeks. Total fatty acid compositions of the plasma and LDL were found to be modulated (but not too drastically) by the nature of the dietary fats. Cholesterol supplementation significantly increased the plasma level of vitamin E and effectively altered the plasma composition of long-chain fatty acids in favor of increasing oleic acid. Oxidative susceptibilities of LDL samples were determined by Cu2+-catalyzed oxidation which provide the lag times and lag-phase slopes. The plasma LDL from all palm oil diets [RBDPO, CPO, and RBDPO(wc)] were shown to be equally resistant to the oxidation, and the LDL from SO-fed rabbits were most susceptible, followed by the LDL from the CNO-fed rabbits. These results reflect a relationship between the oxidative susceptibility of LDL due to a combination of the levels of polyun-saturated fatty acids and vitamin E.
- Steinbrecher, U.P., Zhang, H., and Longheed, M. (1990) Role of Oxidatively Modified LDL in Atherosclerosis,Free Rad. Biol. Med. 9, 155–168. CrossRef
- Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C., and Witztum, J.L. (1989) Beyond Cholesterol: Modifications of Low-Density Lipoprotein that Increase Its Atherogenicity,New Engl. J. Med. 320, 915–924. CrossRef
- Witztum, J.L., and Steinberg, D. (1991) Role of Oxidized Low Density Lipoprotein in Atherogenesis,J. Clin. Invest. 88, 1785–1792.
- Boyd, H.C., Gown, A.M., Wolfbauer, G., and Chait, A. (1989) Direct Evidence for a Protein Recognised by a Monoclonal Antibody Against Oxidatively Modified LDL in Atherosclerotic Lesions from a Watanabe Heritable Hyperlipidemic Rabbit,Am. J. Pathol. 135, 815–825.
- Quinn, M.T., Parthasarathy, S., Fong, L.G., and Steinberg, D. (1987) Oxidatively Modified Low Density Lipoproteins: A Potential Role in Recruitment and Retention of Monocyte/Macrophages During Atherogenesis,Proc. Natl. Acad. Sci.USA 84, 2995–2998. CrossRef
- Stam, H., Hülsman, J.F., Jongkind, J.F., Van der Kraaij, A.M.M., and Koster, J.F. (1989) Endothelial Lesions, Dietary Composition and Lipid Peroxidation,Eicosanoids 2, 1–14.
- Rosenfeld, M.E., Palinski, W., Yla-Herttuala, S., and Carew, T.E. (1990) Macrophages, Endothelial Cells, and Lipoprotein Oxidation in the Pathogenesis of Atherosclerosis,Toxicol. Pathol. 18, 560–571.
- Thompson, G. (1992) Progression and Regression of Coronary Artery Disease,Current Opinion Lipidology 3, 263–267. CrossRef
- Tan, D.T.S., Khor, H.T., Low, W.H.S., Ali, A., and Gapor, A. (1991) Effect of a Palm-Oil-Vitamin E Concentrate on the Serum Lipoprotein Lipids in Humans,Am. J. Clin. Nutr. 53, 1027S-1030S.
- Watkins, T., Lenz, P., Gapor, A., Struck, M., Tomeo, A., and Bierenbuam, M. (1993) γ-Tocotrienol as a Hypocholesterolemic and Antioxidant Agent in Rats Fed Atherogenic Diets,Lipids 28, 1113–1118.
- Holme, I., Enger, S.C., Helgeland, A., Hjermann, I., Leren, P., Lund-Larsen, P.G., Solberg, L.A., and Strong, J.P. (1981) Risk Factors and Raised Atherogenic Lesions in Coronary and Cerebral Arteries. Statistical Analysis from the Oslo Study,Arteriosclerosis 1, 250–256.
- Ledwozyw, A., Michalak, J., Stepien, A., and Kadziolka, A. (1986) The Relationship Between Plasma Triglycerides, Cholesterol, Total Lipids and Lipid Peroxidation Products During Human Atherosclerosis,Clin. Chim. Acta 155, 275–284. CrossRef
- Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G., and Jurgens, G. (1990) Biochemical, Structural, and Functional Properties of Oxidized Low-Density Lipoprotein,Chem. Res. Toxicol. 3, 77–92. CrossRef
- Havel, R.J., Eder, H.A., and Bragdon, J.H. (1955) The Distribution and Chemical Composition of Ultracentrifugally Separated Lipoproteins in Human Serum,J. Clin. Invest. 34, 1345–1353. CrossRef
- Quehenberger, O., Koller, E., Jürgens, G., and Esterbauer, H. (1987) Investigation of Lipid Peroxidation in Human Low Density Lipoprotein,Free Rad. Res. Comm. 3, 233–242.
- Esterbauer, H., Striegl, G., Puhl, H., and Rotheneder, M. (1989) Continuous Monitoring ofin vitro Oxidation of Human Low Density Lipoprotein,Free Rad. Res. Comm. 6, 67–75.
- Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957) A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues,J. Biol. Chem. 226, 497–509.
- Lang, J.K., Gohil, K., and Packer, L. (1986) Simultaneous Determination of Tocopherols, Ubiquinols, Ubiquinones in Blood, Plasma, Tissue Homogenates, and Subcellular Fractions,Anal. Biochem. 157, 106–116. CrossRef
- Blaton, V.H., and Peeters, H. (1972) Integrated Approach to Plasma Lipid and Lipoprotein Analysis,Blood Lipids Lipoproteins: Quantitation Composition and Metabolism (Nelson, G.J., ed.) pp. 275–314, Wiley Interscience, New York.
- Steinbrecher, U.P., Witztum, J.L., Parthasarathy, S., and Steinberg, D. (1987) Decrease in Reactive Amino Groups During Oxidation or Endothelial Cell Modification of LDL. Correlation with Changes in Receptor-Mediated Catabolism,Arteriosclerosis 7, 135–143.
- Esterbauer, H., Rotheneder, M., Striegl, G., Waeg, G., Ashy, A., Sattler, W., and Jurgens, G. (1989) Vitamin E and Other Lipophilic Antioxidants Protect LDL Against Oxidation,Fat Sci. Technol. 91, 316–324.
- Hew, N.F., Khor, H.T., Choo, Y.M., Yap, S.F., and Goh, S.H. (1994) Unusual Accumulation of α-Tocopherol in Rabbits Fed Palm-Oil Diets Enhanced with Various Vitamin E Components,Malaysian J. Sci. 15A, 73–78.
- Esterbauer, H., Jürgens, G., Quehenberger, O., and Koller, E. (1987) Autoxidation of Human Low Density Lipoprotein: Loss of Polyunsaturated Fatty Acids and Vitamin E and Generation of Aldehydes,J. Lipid Res. 28, 495–509.
- Ingold, K.U., Bowry, V.W., Stocker, R., and Walling, C. (1993) Autoxidation of Lipids and Antioxidation by α-Tocopherol and Ubiquinol in Homogeneous Solution and in Aqueous Dispersions of Lipids: Unrecognized Consequences of Lipid Particle Size as Exemplified by Oxidation of Human Low Density Lipoprotein,Proc. Natl. Acad. Sci. USA 90, 45–49. CrossRef
- Chait, A., Brazg, R.L., Tribble, D.L., and Krauss, R.M. (1993) Susceptibility of Small, Dense, Low-Density Lipoproteins to Oxidative Modification in Subjects with the Atherogenic Lipoprotein Phenotype, Pattern B,Am. J. Med. 94, 350–356. CrossRef
- Parthasarathy, S., Khoo, J.C., Muller, E., Barnett, J., Witztum, J.L., and Steinberg, D. (1990) Low Density Lipoprotein Rich in Oleic Acid Is Protected Against Oxidative Modification: Implications for Dietary Prevention of Atherosclerosis,Proc. Natl. Acad. Sci. USA 87, 3894–3898. CrossRef
- Rimm, E.B., Stampfer, M.J., Ascherio, A., Giovannucci, E., Colditz, G.A., and Willet, W.C. (1993) Vitamin E Consumption and the Risk of Coronary Heart Disease in Men,New Engl. J. Med. 328, 1450–1456. CrossRef
- Frankel, E.N., Kanner, J., German, J.B., Parks, E., and Kinsella, J.E. (1993) Inhibition of Oxidation of Human Low-Density Lipoprotein by Phenolic Substances in Red Wine,The Lancet 341, 454–456. CrossRef
- Oxidative susceptibility of low density lipoprotein from rabbits fed atherogenic diets containing coconut, palm, or soybean oils
Volume 30, Issue 12 , pp 1145-1150
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. Palm Oil Research Institute of Malaysia, University of Malaya, 59100, Ruala Lumpur, Malaysia
- 2. Department of Chemistry, University of Malaya, 59100, Kuala Lumpur, Malaysia
- 3. Department of Pathology, University of Malaya, 59100, Kuala Lumpur, Malaysia
- 4. Department of Biochemistry, University of Malaya, 59100, Kuala Lumpur, Malaysia
- 5. Malaysian Palm Oil Promotion Council, 50450, Kuala Lumpur, Malaysia