Lipids

, Volume 27, Issue 11, pp 901–907

First year growth of preterm infants fed standard compared to marine oil n−3 supplemented formula

Authors

  • Susan E. Carlson
    • Department of Pediatrics, Newborn CenterUniversity of Tennessee
    • Department of Obstetrics and Gynecology, Newborn CenterUniversity of Tennessee
    • Department of Biochemistry, Newborn CenterUniversity of Tennessee
  • Richard J. Cooke
    • Department of Pediatrics, Newborn CenterUniversity of Tennessee
    • Department of Obstetrics and Gynecology, Newborn CenterUniversity of Tennessee
  • Susan H. Werkman
    • Department of Pediatrics, Newborn CenterUniversity of Tennessee
    • Department of Obstetrics and Gynecology, Newborn CenterUniversity of Tennessee
  • Elizabeth A. Tolley
    • Department of Biostatistics and Epidemiology, Newborn CenterUniversity of Tennessee
Article

DOI: 10.1007/BF02535870

Cite this article as:
Carlson, S.E., Cooke, R.J., Werkman, S.H. et al. Lipids (1992) 27: 901. doi:10.1007/BF02535870

Abstract

Very low birth weight (VLBW) infants (748–1390 g, n=65) were randomly assigned to receive control or marine oil-supplemented formula when they achieved intakes >454 kJ (110 kcal)/kg/d of a formula designed for VLBW infants. Study formulas with or without marine oil were provided until 79 wk of postconceptional age (PCA), first in a formula designed for preterm infants followed by a formula designed for term infants. Infants were studied at regular intervals through 92 wk PCA. Weight, length, and head circumference were determined by standardized prodedures and normalized to the National Center for Health Statistics figures for growth of infants born at term of the same age and gender. Mean normalized weight, weight-to-length, and head circumference were greatest at 48 wk and decreased thereafter. The decline in normalized weight was greater in infants fed the marine oil-supplemented formula. Beginning at 40 wk, marine oil-supplemented infants compared to controls had significantly poorer Z-scores for weight, length and head circumference. In addition, birth order (negatively) and maternal height (positively) influenced weight and length achievement in infancy as shown previously in infants born at term.

Abbreviations

AGA

appropriate-for-gestational age

ANOVA

analysis of variance

BPD

bronchopulmonary dysplasia

DHA

docosahexaenoic acid

EPA

eicosapentaenoic acid

PCA

postconceptional age

SGA

small for gestational age

VLBW

very low birth weight

Copyright information

© American Oil Chemists’ Society 1992