Interrelationship between dietarytrans fatty acids and the 6- and 9-desaturases in the rat
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Studies are reported on the effects of dietarytrans fatty acids on the 6- and 9-acyl desaturase activities in the liver microsomes of rats fed essential fatty acid (EFA)-deficient and non-FFA-deficient diets. In experiment I, weanling male rats were fed a semisynthetic diet with either 10% safflower oil (SAF) or 10% hydrogenated coconut oil (HCO). At the age of one year, half of the dietary fat was replaced by a supplement containing elaidate, linolelaidate andcis,trans-trans,cis-18∶2 (TRANS) for 12 weeks. In experiment II, male rats which were kept from weaning on a 10% SAF diet for one year received one of the following fat supplements for a 12-week period: 10% HCO, 9% HCO+1% TRANS, or 5% HCO+5% TRANS. Feeding TRANS depressed the 6-desaturase activity in the liver microsomes, especially in the EFA-deficient rats (HCO+TRANS group of experiment I). Unlike the 6-deaturase activity, the 9-desaturase activity was not inhibited by the dietarytrans fatty acids and was significantly stimulated in the non-EFA-deficient rats (SAF+TRANS group of experiment I and HCO+TRANS groups of experiment II). This was evidenced by incubation reactions and by comparisons of fatty acid consumptions and microsomal fatty acid levels, showing extra biosynthesis of 16∶1 and 18∶1 when TRANS was fed. The biosynthesis of essential (n−6) fatty acids was depressed by the TRANS supplement in EFA-deficient as well as in non-EFA-deficient animals.
- Takatori, T., Phillips, F.C., Shimasaki, H., and Privett, O.S. (1976) Lipids 11, 272–280. CrossRef
- Privett, O.S., Phillips, F.C., Shimasaki, H., Nozawa, T., and Nickell, E.C. (1977) Am. J. Clin. Nutr. 30, 1009–1017.
- Privett, O.S., Sterns, E.M., and Nickell, E.C. (1967) J. Nutr. 92, 303–310.
- Privett, O.S., and Blank, M.L. (1964) J. Am. Oil Chem. Soc. 41, 292–297.
- Johnston, P.V., Kummerow, F.A., and Walton, C.H. (1958) Proc. Soc. Exp. Biol. Med. 99, 735–736
- Sgoutas, D., and Kumerow, F.A. (1970) Am. J. Clin. Nutr. 23, 1111–1119.
- Egwim, P.O., and Kummerow, F.A. (1972) J. Nutr. 102, 783–792.
- Schrock, C.G., and Connor, W.E. (1975) Am. J. Clin. Nutr. 28, 1020–1027.
- Wood, R., and Wiegand, R.D. (1975) Lipids 10, 746–749. CrossRef
- Heckers, H., Körner, M., Tüschen, T.W.L., and Melcher, F.W. (1977) Atherosclerosis 28, 389–398. CrossRef
- Lemarchal, P., and Munsch, N. (1965) C.R. Soc. Biol. 260, 714–716.
- Lemarchal, P. (1966) C.R. Soc. Biol. 262, 816–819.
- Dhopeshwarker, G.A., and Mead, J.F. (1962) J. Lipid Res. 3, 238–242.
- Karney, R.I., and Dhopeshwarkar, G.A. (1978) Biochim. Biophys. Acta 531, 9–15.
- Anderson, R.L., Fullmer, C.S., and Hollenbach, E.J. (1975) J. Nutr. 105, 393–400.
- Houtsmuller, U.M.T. (1978) Fette Seifen Anstrichm. 80, 162–169. CrossRef
- Brenner, R.R., and Peluffo, R.O. (1969) Biochim. Biophys. Acta 176, 471–479.
- Mahfouz, M.M., Johnson, S., and Holman, R.T. (1980) Lipids 15, 100–107. CrossRef
- Kurata, N., and Privett, O.S. (1980) Lipids 15, 1029–1036. CrossRef
- Inkpen, C.A., Harris, R.A., and Quackenbusch, F.W. (1969) J. Lipid Res. 10, 277–282.
- Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) J. Biol. Chem. 193, 265–275.
- Privett, O.S., and Nutter, L.J. (1967) Lipids 2, 149–154. CrossRef
- Marcel, Y.L., Christiansen, K., and Holman, R.T. (1968) Biochim. Biophys. Acta 164, 25–34.
- Castuma, J.C., Catala, A., and Brenner, R.R. (1972) J. Lipid Res. 13, 783–789.
- Sprecher, H. (1974) Biochim. Biophys. Acta 360, 113–123.
- Guo, L.S.S., and Alexander, J.C. (1974) Biochim. Biophys. Acta 369, 411–420.
- Interrelationship between dietarytrans fatty acids and the 6- and 9-desaturases in the rat
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