Lipids

, Volume 22, Issue 9, pp 669–671

Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats

  • Toshiyuki Chikai
  • Hiroyuki Nakao
  • Kiyohisa Uchida
Communications

DOI: 10.1007/BF02533948

Cite this article as:
Chikai, T., Nakao, H. & Uchida, K. Lipids (1987) 22: 669. doi:10.1007/BF02533948

Abstract

Fecal bile acids in germ-free rats were analyzed after inoculation withBacteroides vulgatus, Bifidobacterium longum, Escherichia coli orClostridium ramosum. B. vulgatus preferentially deconjugated tauro-β-muricholic acid andB. longum taurocholic acid.C. ramosum deconjugated both bile acids, butE. coli deconjugated neither. 7α-Dehydroxylation of bile acids was negligible even after 18 days of inoculation, but a small amount of 7-oxo-bile acid, less than 5%, was formed. Fecal excretion of bile acids increased after inoculation withB. vulgatus, B. longum andC. ramosum, but not withE. coli.

Copyright information

© American Oil Chemists’ Society 1987

Authors and Affiliations

  • Toshiyuki Chikai
    • 2
  • Hiroyuki Nakao
    • 1
  • Kiyohisa Uchida
    • 2
  1. 1.Shionogi Aburahi LaboratoriesShigaJapan
  2. 2.Shionogi Research LaboratoriesShionogi & Co.OsakaJapan