Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats
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- Chikai, T., Nakao, H. & Uchida, K. Lipids (1987) 22: 669. doi:10.1007/BF02533948
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Fecal bile acids in germ-free rats were analyzed after inoculation withBacteroides vulgatus, Bifidobacterium longum, Escherichia coli orClostridium ramosum. B. vulgatus preferentially deconjugated tauro-β-muricholic acid andB. longum taurocholic acid.C. ramosum deconjugated both bile acids, butE. coli deconjugated neither. 7α-Dehydroxylation of bile acids was negligible even after 18 days of inoculation, but a small amount of 7-oxo-bile acid, less than 5%, was formed. Fecal excretion of bile acids increased after inoculation withB. vulgatus, B. longum andC. ramosum, but not withE. coli.