European Journal of Pediatrics

, Volume 155, Issue 12, pp 1015–1017

Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease

  • T. A. De Heer-Groen
  • A. B. J. Prakken
  • N. M. A. Bax
  • P. J. van Dijken
Hematology/Oncology

DOI: 10.1007/BF02532521

Cite this article as:
De Heer-Groen, T.A., Prakken, A.B.J., Bax, N.M.A. et al. Eur J Pediatr (1996) 155: 1015. doi:10.1007/BF02532521

Abstract

Abstract

We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely.

Conclusion

Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergam-maglobulinaemia.

Key words

Castleman disease Microcytic anaemia Childhood 

Abbreviations

CRP

C-reactive protein

ESR

erythrocyte sedimentation rate

HV

hyaline-vascular type of Castleman disease

Il-6

interleukin-6

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • T. A. De Heer-Groen
    • 1
  • A. B. J. Prakken
    • 3
  • N. M. A. Bax
    • 3
  • P. J. van Dijken
    • 2
  1. 1.Hospital Centre ApeldoornThe Netherlands
  2. 2.Riyadh Armed Forces HospitalKingdom of Saudi Arabia
  3. 3.‘Het Wilhelmina Kinderziekenhuis’University Hospital for Children and YouthUtrechtThe Netherlands

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