Neurochemical Research

, Volume 21, Issue 11, pp 1369–1373

Cyclazocine revisited

  • Sydney Archer
  • Stanley D. Glick
  • Jean M. Bidlack
Physiology and Behavior

DOI: 10.1007/BF02532378

Cite this article as:
Archer, S., Glick, S.D. & Bidlack, J.M. Neurochem Res (1996) 21: 1369. doi:10.1007/BF02532378


Recently synthesized compounds which have long-term mu antagonist activity and short-term kappa agonist effects prevent self-administration of cocaine and morphine in rats. Cyclazocine, a compound synthesized in 1962 and studied in animals and man in the 1960's and in the early 1970's is a mu antagonist in rats and man and is a potent kappa agonist in both species. It also prevents self-administration of cocaine and morphine in rats. Although it produces unpleasant side effects in man, subjects become tolerant to these side effects but not to the antagonistic actions of the drug after prolonged administration.

Key words

Cyclazocine mu antagonist kappa agonist 

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Sydney Archer
    • 1
  • Stanley D. Glick
    • 2
  • Jean M. Bidlack
    • 3
  1. 1.Department of ChemistryRensselaer Polytechnic InstituteTroy
  2. 2.Department of Pharmacology and NeuroscienceAlbany Medical CollegeAlbany
  3. 3.Department of Pharmacology and PhysiologyUniversity of Rochester, School of Medicine and DentistryRochester

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