Neurochemical Research

, Volume 21, Issue 7, pp 787–793

Neurotrophin-4: The odd one out in the neurotrophin family

  • Carlos F. Ibáñez
Original Articles

DOI: 10.1007/BF02532301

Cite this article as:
Ibáñez, C.F. Neurochem Res (1996) 21: 787. doi:10.1007/BF02532301


Neurotrophin-4 (NT-4) is a member of a family of neurotrophic factors, the neurotrophins, that control survival and differentiation of vertebrate neurons (2–4). Besides being the most recently discovered neurotrophin in mammals, and the least well understood, several aspects distinguish NT-4 from other members of the neurotrophin family. It is the most divergent member and, in contrast to the other neurotrophins, its expression is ubiquitous and appears to be less influenced by environmental signals. NT-4 seems to have the unique requirement of binding to the lowaffinity neurotrophin receptor (p75LNGFR) for efficient signalling and retrograde transport in neurons. Moreover, while all other neurotrophin knock-outs have proven lethal during early postnatal development, mice deficient in NT-4 have so far only shown minor cellular deficits and develop normally to adulthood. Is NT-4 a recent addition to the neurotrophic factor repertoire in search of a crucial function, or is it an evolutionary relic, a kind of wisdom tooth of the neurotrophin family?

Key Words

Developmentmusclenervous systemnerve growth factorsite-directed mutagenesis

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Carlos F. Ibáñez
    • 1
  1. 1.Department of Medical Biochemistry and Biophysics, Laboratory of Molecular NeurobiologyKarolinska InstituteStockholmSweden