Molecules inhibiting neurite growth: A minireview
- Martin E. Schwab
- … show all 1 hide
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Molecules and activities which repulse growing neurites or induce growth cone collapse and long-lasting growth inhibition have been defined over the last 10 years. Recently, specific guidance roles for developing axons and pathways could be associated with such repulsive effects. A high molecular weight membrane protein located in CNS myelin acts as potent neurite growth inhibitor and may play a role as a negative control element for sprouting, neurite growth and regeneration, and for the plasticity of the adult CNS. Interestingly, some guidance molecules can have positive, growth-promoting as well as negative, repulsive effects for specific types of neurons. These results underline the complex mechanisms involved in neurite guidance which depends on the interpretation of combinations of incoming signals by particular growth cones.
Special issue dedicated to Dr. Hans Thoenen.
Thoenen, H. and Barde, Y.-A. 1980. Physiology of nerve growth factor. Physiol. Reviews 60:1284–1335
Teng, K. K., and Greene, L. A. 1994 KT5926 selectively inhibits nerve growth factor-dependent neurite elongation. J. Neurosci. 14: 2624–2635.PubMed
Schwab, m. E., Kapfhammer, J. P., and Bandtlow, C. E. 1993. Inhibitors of neurite growth. In Annual Review of Neuroscience. W. M. Cowan, editor. Annual Rev. Inc., Palo Alto., Vol. 16, 565–595.
Stern, C. D., Sisodiya, S. M., and Keynes, R. J. 1986. Interactions between neurites and somite cells: inhibition and stimulation of nerve growth in the chick embryo. J. Embriol. Exp. Morphol. 91: 209–226.
Schwab, M. E., and Thocnen, H. 1985. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J. Neurosci. 5:2415–2423.PubMed
Kapfhammer, J. P., Grunewald, B. E., and Raper, J. A. 1986. The selective inhibition of growth cone extension by specific neurites in culture. J. Neurosci. 6:2527–2534.PubMed
Walter, J., Henke-Fahle, S., and Bonhoeffer, F. 1987. Avoidance of posterior tectal membranes by temporal retinal axons. Devl. 101:909–913.
Davies, J. A., Cook, G. M. W., Stern, C. D., and Keynes, R. J. 1990. Isolation from chick somites of a glycoprotein fraction that causes collapse of dorsal root ganglion growth cones. Neuron 2: 11–20.CrossRef
Raper, J. A., and Kapfhammer, J. P. 1990. The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain. Neuron 2:21–29.CrossRef
Kater, S. B., and Mills, L. R. 1991. Regulation of growth cone behavior by calcium. J. Neurosci. 11:891–899.PubMed
Oohira, A., Matsui, F., and Katho-Semba, R. 1991. Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite out-growth from PC12D cells. J. Neurosci. 11:822–827.PubMed
Schwab, M. E., and Bartholdi, D. 1996. Degeneration and regeneration of axons in the lesioned spinal cord. Physiol. Rev. 76:319–370.PubMed
Clarke, G. A., and Moss, D. J. 1994. Identification of a novel protein from adult chicken brain that inhibits neurite outgrowth. J. Cell Sci. 107:3393–3402.PubMed
Bandtlow, C. E., Zachleder, T., and Schwab, M. E. 1990. Oligo-dendrocytes arrest neurite growth by contact inhibition. J. Neurosci. 10:3837–3848.PubMed
Schwab, M. E., and Schnell, L. 1991. Channelling of developing rat corticospinal tract axons by myelin-associated neurite growth inhibitors. J. Neurosci. 11:709–722.PubMed
Kapfhammer, J., Schwab, M. E., and Schneider, J. 1992. Antibody neutralization of neurite growth inhibitors from oligodendrocytes results in expanded pattern of postnatally sprouting retinocollicular axons. J. Neurosci. 12:2112–2119.PubMed
Colello, R. J., and Schwab, M. E. 1994. A role for oligodendrocytes in the stabilization of optic axon numbers. J. Neurosci. 14: 6446–6452.PubMed
Schwegler, G., Schwab, M. E., and Kapfhammer, J. P. 1995. Increased collateral sprouting of primary afferents in the myelin-free spinal cord. J. Neurosci. 15:2756–2767.PubMed
Cadelli, D., and Schwab, M. E. 1991. Regeneration of lesioned septohippocampal acetylcholinesterase-positive axons is improved by antibodies against the myelin-associated neurite growth inhibitors NI-35/250. Europ. J. Neurosci. 3:825–832.CrossRef
Schnell, L., and Schwab, M. E. 1993. Sprouting and regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord. Europ. J. Neurosci. 5:1156–1171.CrossRef
Serafini-Kennedy, T. E., Galko, M. J., Mirzayan, C., Jessel, T. M., and Tessier-Lavigne, M. 1994. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78:409–424.CrossRef
Mukhopadhyay, G., Doherty, P., Walsh, F. S., Crocker, P. R., and Filbin, M. Y. 1994. A novel role of myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13:1–20.CrossRef
Bartsch, U. Bandtlow, C. E., Schnell, L., Bartsch, S., Spillmann, A. A., Rubin, B. P., Montag, D., Schwab, M. E., and Schachner, M. 1995. Lack of evidence that the myelin-associated glycoprotein (MAG) is a major inhibitor of axonal regeneration in the CNS. Neuron 15:1376–1381.CrossRef
Bartsch, U., Bartsch, S., Dörries, U., and Schachner, M. 1992. Immunohistological localization of tenascin in the developing and lesioned adult mouse optic nerve. Europ. J. Neurosci. 4:338–352.CrossRef
Bartsch, S., Husmann, K., Schachner, M., and Bartsch, U. 1995. The extracellular matrix molecule tenascin: expression in the developing chick retinotectal system and substrate properties for retinal ganglion cell neurites in vitro. Europ. J. Neurosci. 7:907–916.CrossRef
Wehrle-Haller, B., and Chiquet, M. 1993. Dual function of tenascin: simultaneous promotion of neurite growth and inhibition of glial migration. J. Cell. Sci. 106:597–610.PubMed
Wehrle, B., and Chiquet, M. 1990. Tenascin is accumulated along developing peripheral nerves and allows neurite outgrowth in vitro. Development 110:401–415.PubMed
Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., and Aizawa, S. 1992. Mice develop normally without tenascin. Genes Dev. 6:1821–1831.PubMed
Rathjen, F. G., Wolff, J. M., and Chiquet-Ehrismann, R. 1991. Restrictin: a chick neural extracellular matrix protein involved in cell attachment co-purifies with the cell recognition molecule F11. Devl. 113:151–164.
Nörenberg, U., Hubert, M., Brümmendorf, T., Tarnok, A., and Rathjen, F. G. 1995. Characterization of functional domains of the tenascin-R (restrictin) polypeptide: cell attachment site, binding with F11, and enhancement of F11-mediated neurite outgrowth by tenascin-R. J. Cell Biol. 130:473–484.PubMedCrossRef
Wintergerst, E. S., Fuss, B., and Bartsch, U. 1993. Localization of Janusin mRNA in the central nervous system of the developing and adult mouse. Europ. J. Neurosci. 5:299–310.CrossRef
Boyolenta, P., Wandosell, F., and Nieto-Sampedro, M. 1993. Characterization of a neurite outgrowth inhibitor expressed after CNS injury. Europ. J. Neurosci. 5:454–465.CrossRef
Katoh-Semba, R., Matsuda, M., Kato, K., and Oohira, A. 1995. Chondroitin sulphate proteoglycans in the rat brain: candidates for axon barriers of sensory neurons and the possible modification by laminin of their actions. Europ. J. Neurosci. 7:613–621.CrossRef
Geisert Jr., E. E., and Bidanset, D. J. 1993. A centrla nervous system keratan sulfate proteoglycan: localization to boundaries in the neonatal rat brain. Devl. Brain Res. 75:163–173.CrossRef
Levinc, J. M. 1994. Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury. J. Neurosci 14:4716–4730.
Snow, D. M., Watanabe, M., Letourneau, P. C., and Silver, J. 1991. A chondroitin sulfate proteoglycan may influence the direction of retinal ganglion cell outgrowth. Devl. 113:1473–1485.
- Molecules inhibiting neurite growth: A minireview
Volume 21, Issue 7 , pp 755-761
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- growth cone
- Industry Sectors
- Martin E. Schwab (1)
- Author Affiliations
- 1. Brain Research Institute, University of Zurich, August Forel-Str. 1, 8029, Zurich, Switzerland