Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits

  • R. Bray
  • K. Forrester
  • J. J. McDougall
  • A. Damji
  • W. R. Ferrell
Imaging

DOI: 10.1007/BF02520078

Cite this article as:
Bray, R., Forrester, K., McDougall, J.J. et al. Med. Biol. Eng. Comput. (1996) 34: 227. doi:10.1007/BF02520078

Abstract

Laser Doppler imaging (LDI) is investigated as a novel method for in vivo ligament tissue blood flow determination. LDI output signal is obtained from surgically exposed rabbit medial collateral ligaments (MCL). The LDI signal, is compared with simultaneously determined, coloured microsphere (CM)-derived standardised MCL blood flow. Correlation of LDI output with the CM flow data and a linear regression of 17 data points in nine rabbits (joint injured to provoke an acute vascular response in the tissues) indicate that LDI provides a reasonable estimate of MCL blood flow, at least over the ranges assessed. If properly calibrated, and given enough tissue-specific data points, LDI may have advantages over conventional, but more invasive, techniques. The potential clinical application of LDI technology to joint injury and arthritis research is discussed.

Keywords

Blood flow Healing Injury Laser Doppler Ligament Rabbits 

Copyright information

© IFMBE 1996

Authors and Affiliations

  • R. Bray
    • 1
  • K. Forrester
    • 1
  • J. J. McDougall
    • 2
  • A. Damji
    • 1
  • W. R. Ferrell
    • 2
  1. 1.McCaig Centre for Joint Injury and Arthritis Research, Department of Surgery, Faculty of MedicineUniveristy of CalgaryCalgaryCanada
  2. 2.Institute of Biomedical & Life Sciences, Division of Neuroscience & Biomedical SystemsUniversity of GlasgowGlasgowUK

Personalised recommendations