Journal of Molecular Evolution

, Volume 32, Issue 2, pp 101–104

Pyrophosphate formation as the most efficient condensation reaction of activated nucleotides

Authors

  • Libaniel Rodriguez
    • The Salk Institute for Biological Studies
  • Leslie E. Orgel
    • The Salk Institute for Biological Studies
Article

DOI: 10.1007/BF02515382

Cite this article as:
Rodriguez, L. & Orgel, L.E. J Mol Evol (1991) 32: 101. doi:10.1007/BF02515382

Summary

When an oligonucleotide primer pG10 is incubated with the nucleotide analogue 9-[3-hydroxy-2-(hydroxymethyl)prop-1-yl] guanine diphosphate (\(p\overline{\overline G} p\), I) in the presence of poly(C), addition of the monomer occurs almost exclusively at the 5′-terminal phosphate rather than the 3′-terminalcis-glycol. The implications of this finding in the context of prebiotic condensation reactions are discussed.

Key words

Pyrophosphate formationTemplate-directed synthesisNucleotide analogues
Download to read the full article text

Copyright information

© Springer-Verlag New York Inc 1991