Chromatographia

, Volume 52, Issue 3, pp 245–248

Simultaneous GC determination of turpentine, camphor, menthol and methyl salicylate in a topical analgesic formulation (Dologex®)

  • E. González-Peñas
  • M. López-Alvarez
  • F. Martínez de Narvajas
  • A. Ursúa
Short Communications Gas Chromatography

DOI: 10.1007/BF02490466

Cite this article as:
González-Peñas, E., López-Alvarez, M., Martínez de Narvajas, F. et al. Chromatographia (2000) 52: 245. doi:10.1007/BF02490466

Summary

A gas chromatographic assay has been developed for the simultaneous quantitative determination of turpentine, camphor, methol and methyl salicylate in a topical formualtion (Dologex®). Eucalyptol was used as the internal standard. Compounds were separated on a cross-linked 5% phenyl polydimethylsiloxane capillary column and detected by FID. The method was validated on the basis of selectivity, recovery, linearity, precision and accuracy. Calibration graphs were linear for each analyte in the range studied. Intra and inter-day precision (coefficient of variation,CV) did not exceed 2%. The applicability of the method was demonstrated in a stability study of these compounds in samples of the formulation which had been maintained under different temperature conditions for six months.

Key Words

Gas chromatographyTurpentineCamphorMetholMethyl salicylate

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2000

Authors and Affiliations

  • E. González-Peñas
    • 1
  • M. López-Alvarez
    • 1
  • F. Martínez de Narvajas
    • 2
  • A. Ursúa
    • 2
  1. 1.Departamento de Química Orgánica y Farmacéutica. Facultad de FarmaciaUniversidad de NavarraPamplonaSpain
  2. 2.Laboratorios CINFA S.A.PamplonaSpain