Chromatographia

, Volume 53, Supplement 1, pp S231–S235

Optimization of conditions for the liquid chromatographic-electrospray lonization-mass spectrometric analysis of amnesic shellfish poisoning toxins

  • N. Piñeiro
  • E. Vaquero
  • J. M. Leão
  • A. Gogo-Martínez
  • J. A. Rodríguez Vázquez
Originals Column Liquid Chromatography

DOI: 10.1007/BF02490333

Cite this article as:
Piñeiro, N., Vaquero, E., Leão, J.M. et al. Chromatographia (2001) 53: S231. doi:10.1007/BF02490333

Summary

In this paper we report results obtained from analysis of domoic acid and its analogues, toxins responsible for incidents of amnesic shellfish poisoning (ASP) in several places world-wide, by use of liquid chromatography coupled with electrospray ionization mass spectrometry. Different chromatographic and mass spectrometry conditions were evaluated with the aim of achieving the best chromatographic performance combined with the optimum mass spectrometric response. From the results obtained it can be concluded that LC-MS is powerful tool for the selective and sensitive determination of domoic acid and its isomers in naturally contaminated samples.

Key Words

Liquid chromatography-mass spectrometryAmnesic shellfish poisoning toxinsOptimization of parameters

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2001

Authors and Affiliations

  • N. Piñeiro
    • 1
  • E. Vaquero
    • 1
  • J. M. Leão
    • 1
  • A. Gogo-Martínez
    • 1
  • J. A. Rodríguez Vázquez
    • 1
  1. 1.Departamento de Química Analítica y AlimentariaUniversidad de VigoVigoSpain