Brain Tumor Pathology

, Volume 21, Issue 3, pp 127–133

Chromosomal and genetic aberrations differ with meningioma subtype

Authors

  • Kouichi Wada
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Tsuyoshi Suzuki
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Naoki Kagawa
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Tetsuo Hashiba
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Yasunori Fujimoto
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Naoya Hashimoto
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Shuichi Izumoto
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
  • Toshiki Yoshimine
    • Department of NeurosurgeryOsaka University Graduate School of Medicine
Original Article

DOI: 10.1007/BF02482188

Cite this article as:
Wada, K., Maruno, M., Suzuki, T. et al. Brain Tumor Pathol (2004) 21: 127. doi:10.1007/BF02482188

Abstract

Meningioma is one of the most common brain tumors, and a variety of genetic abnormalities have been detected by the Southern blotting, polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH) methods. However, these methods detect only a very limited portion of the tumor genome or have a limited mapping resolution. In this study, we used DNA microarray assay, which detects numerous genetic abnormalities and analyzes a global assessment of molecular events in tumor cells. We analyzed genomic DNA from 26 patients with benign meningiomas by GenoSensor Array 300 in order to characterize gene amplifications, gene deletions, and chromosomal information in the whole genome. Loss of chromosome 22q was found most frequently. This chromosomal aberration was detected in 14 meningiomas (53.8%), particularly in transitional and fibrous meningiomas. In meningothelial meningiomas, amplification ofINS andTCL1A was detected more frequently than in other meningioma subtypes. DNA microarray assay revealed new genetic differences among the meningioma subtypes, thus indicating that this novel technique is useful for understanding tumor genesis and for the diagnosis of meningioma subtype.

Key words

MeningiomaSubtypeDNA microarray assayAmplificationDeletion

Copyright information

© The Japan Society of Brain Tumor Pathology 2004