Clinical and Experimental Nephrology

, Volume 2, Issue 4, pp 307–312

Mechanisms of progressive glomerulosclerosis and tubulointerstitial fibrosis

  • Richard J. Johnson
  • Christian Hugo
  • Leah Haseley
  • Raimund Pichler
  • James Bassuk
  • Susan Thomas
  • Shinichi Suga
  • William G. Couser
  • Stuart J. Shankland
Frontiers of Nephrology Part 3: Glomerular Scarring and Interstitial Fibrosis

DOI: 10.1007/BF02480459

Cite this article as:
Johnson, R.J., Hugo, C., Haseley, L. et al. Clin Exper Neph (1998) 2: 307. doi:10.1007/BF02480459

Abstract

In this paper we provide an overview of the cellular changes that accompany progressive glomerulosclerosis and tubulointerstitial fibrosis. Emphasis is placed on the role of platelet-derived growth factor (PDGF) in the proliferation of the mesangial cell and interstitial fibroblast. PDGF also stimulates the synthesis and expression of a protein called secreted protein acidic and rich in cysteine (SPARC) and of thrombospondin 1 (TSP1). TSP1 may have an important role in the conversion of transforming growth factor (TGF)-β from its latent to active form. In turn, TGF-β appears to have a major role in mediating the extracellular matrix deposition that occurs with progressive glomerular and interstitial scarring.

Key words

glomerulosclerosis interstitial fibrosis PDGF TGF-β SPARC thrombospondin 1 

Copyright information

© CEN/CLJ 1998

Authors and Affiliations

  • Richard J. Johnson
    • 1
  • Christian Hugo
    • 1
  • Leah Haseley
    • 1
  • Raimund Pichler
    • 1
  • James Bassuk
    • 1
  • Susan Thomas
    • 1
  • Shinichi Suga
    • 1
  • William G. Couser
    • 1
  • Stuart J. Shankland
    • 1
  1. 1.Division of NephrologyUniversity of Washington Medical CenterSeattleUSA