Brain Tumor Pathology

, Volume 20, Issue 1, pp 7–12

Immunohistochemical expression of E-cadherin in metastatic brain tumors

  • Hamisi Kimaro Shabani
  • Gaspar Kitange
  • Keishi Tsunoda
  • Takeo Anda
  • Yoshiharu Tokunaga
  • Shobu Shibata
  • Makio Kaminogo
  • Tomayoshi Hayashi
  • H. Ayabe
  • Masachika Iseki
Original Article

DOI: 10.1007/BF02478941

Cite this article as:
Shabani, H.K., Kitange, G., Tsunoda, K. et al. Brain Tumor Pathol (2003) 20: 7. doi:10.1007/BF02478941

Abstract

The adhesion molecule E-cadherin has been shown to influence malignant transformation of tumors, including local and distant metastases. We examined the expression of E-cadherin to determine its relationship to the development of metastasis in metastatic brain tumors. Immunohistochemistry for E-cadherin and Ki-67 was carried out in 76 formalin-fixed, paraffin-embedded archival specimens of metastatic brain tumors and in 14 corresponding available primary tumors from patients who received treatment for metastatic brain tumors. The primary tumors were mainly lung cancers (51.3%), followed by gastrointestinal tumors (28.9%). E-cadherin was expressed in 62 (81.5%) of 76 cases examined. In metastatic adenocarcinomas, a consistent tendency for E-cadherin expression was noted, regardless of the degree of differentiation or the extent of spread of the disease (P=0.4). There was a direct correlation between E-cadherin expression and high MIB-1 index in all metastatic brain tumors (P=0.0007). Pairwise analysis in 14 primary tumors and the corresponding metastatic specimens revealed high E-cadherin and MIB-1 staining in metastatic brain tumors. These results provide a unique association between E-cadherin, systemic metastasis, and proliferation potential in metastatic brain tumors.

Key words

Cadherin Brain tumor metastasis Hematogenous metastasis 

Copyright information

© The Japan Society of Brain Tumor Pathology 2003

Authors and Affiliations

  • Hamisi Kimaro Shabani
    • 1
  • Gaspar Kitange
    • 2
  • Keishi Tsunoda
    • 1
  • Takeo Anda
    • 1
  • Yoshiharu Tokunaga
    • 1
  • Shobu Shibata
    • 1
  • Makio Kaminogo
    • 1
  • Tomayoshi Hayashi
    • 3
  • H. Ayabe
    • 4
  • Masachika Iseki
    • 3
  1. 1.Department of NeurosurgeryNagasaki University School of MedicineNagasakiJapan
  2. 2.Department of Laboratory Medicine and Pathology, Division of Laboratory GeneticsMayo ClinicRochesterUSA
  3. 3.Department of PathologyNagasaki University School of MedicineNagasakiJapan
  4. 4.First Department of SurgeryNagasaki University School of MedicineNagasakiJapan

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