Original Article

Brain Tumor Pathology

, Volume 14, Issue 1, pp 27-33

First online:

Expression and role of cadherins in astrocytic tumors

  • Kenichiroh AsanoAffiliated withDepartment of Neurosurgery, Hirosaki University, School of MedicineDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
  • , Osami KuboAffiliated withDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
  • , Yasuhiko TajikaAffiliated withDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
  • , Ming-Chao HuangAffiliated withDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
  • , Kintomo TakakuraAffiliated withDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical College
  • , Kunihiko EbinaAffiliated withDepartment of Neurosurgery, Hirosaki University, School of Medicine
  • , Shigeharu SuzukiAffiliated withDepartment of Neurosurgery, Hirosaki University, School of Medicine

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Abstract

Cadherins are Ca2+-dependent cell adhesion molecules that play an important role in tissue formation and morphogenesis in multicellular organisms. In recent years, there have been reports of cadherin involvement in tumor invasion and metastasis. Twenty-two surgical specimens and some cultured cells were studied by immunohistochemical staining. No significant difference was observed in the patients with anaplastic astrocytoma, whereas decreased expression of N-cadherin was detected at the time of recurrence in those with glioblastoma. In these groups, cerebrospinal fluid dissemination was found, and contralateral cerebral metastases and extracranial metastases were observed. We conclude that decreased N-cadherin expression at the immunohistochemically demonstrated time of recurrence correlates with tumor invasion and dissemination of cerebrospinal fluid.

Key words

N-cadherin E-cadherin Glioblastoma Anaplastic astrocytoma Dissemination Invasion