The bulletin of mathematical biophysics

, Volume 23, Issue 2, pp 173-195

First online:

Contributions to the theory of active transport: III. The effect of drugs on active transport systems

  • Clifford S. PatlakAffiliated withSection on theoretical Statistics and Mathematics, National Institute of Mental Health, National Institutes of Health

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The addition of a drug to a system which contains an active transport mechanism may produce a large number of effects on both the active transport mechanism and the permeability of the system. A general model of such a system is presented, and various possible results of the drug's addition are discussed. Methods of experimentally separating these effects on the active transport mechanism and the permeabilities of the system are then listed and analyzed.