Hypothalamic and rate feedback in the thyroid hormone regulation system: An hypothesis
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- Distefano, J.J. Bulletin of Mathematical Biophysics (1969) 31: 233. doi:10.1007/BF02477003
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Several alternative models of the system regulating the plasma concentration of thyroid hormones are presented and investigated from the point of view of certain optimal system performance indices. The models differ from each other in the number and types of feed-back pathways. Various combinations of thyroid hormone feedback actions at pituitary and/or hypothalamic chemoreceptor sites, having proportional and/or rate characteristics, are considered in terms of minimum energy consumption and minimum sensitivity to the maximum number of model parameters likely to vary. It is concluded that the model which includes proportional inhibitory feedback of thyroid hormone at the hypothalamic level and rate feedback of thyroid hormone at the level of the pituitary provides the best performance.