The bulletin of mathematical biophysics

, Volume 32, Issue 4, pp 475–483

A note on the dispersionless growth law for single cells

  • E. Trucco
  • G. I. Bell
Article

DOI: 10.1007/BF02476766

Cite this article as:
Trucco, E. & Bell, G.I. Bulletin of Mathematical Biophysics (1970) 32: 475. doi:10.1007/BF02476766

Abstract

A population of initially synchronized cells is considered wherein each cell grows according to a dispersionless growth law and the probability of cell division is determined by cell age. The first and second moments of the distribution of birth volumes are considered as functions of time and it is shown that it is impossible for both moments to approach finite, nonzero limits ast→∞. This implies that the volume distribution of the population will not approach a limiting distribution on any finite, nonzero volume interval and that the population will not attain balanced exponential growth. An illustrative example is worked out in detail. The distribution of birth volumes is also analyzed as a function of generation number and it is found that the logarithm of the birth volume in thejth generation is normally distributed asj→∞, with an unbounded variance. Generalizations and implications of these results are briefly discussed.

Copyright information

© N. Rashevsky 1968

Authors and Affiliations

  • E. Trucco
    • 1
  • G. I. Bell
    • 2
  1. 1.Division of Biological and Medical ResearchArgonne National LaboratoryArgonne
  2. 2.Theoretical Division Los Alamos Scientific LaboratoryUniversity of CaliforniaLos Alamos

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