Abstract
Erythrocytes from a patient with blood type of A1 became nongenetically reactive with A (anti-B) serum, following the development of gastric cancer. Transient polyagglutinability was also apparent. Thein vitro acetylation of the erythrocyte antigens abolished both the acquired B antigen and the polyagglutination. Although incubation of the heterologous type A1 erythrocytes with the patient's serum did not produce B antigen, deacetylase activity in the serum seems to relate to the acquired B antigen. In this case, either ileus as a result of metastatic adenocarcinoma of the stomach, or urinary tract infections could be the cause of the acquired B antigen.
References
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Matsushita, S., Imamura, T., Mizuta, T. et al. Acquired B antigen and polyagglutination in a patient with gastric cancer. The Japanese Journal of Surgery 13, 540–542 (1983). https://doi.org/10.1007/BF02469500
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DOI: https://doi.org/10.1007/BF02469500