, Volume 52, Issue 1-2, pp 209-240

A mathematical theory of natural and artificial selection—I

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Mathematical expressions are found for the effect of selection on simple Mendelian populations mating at random. Selection of a given intensity is most effective when amphimixis does not affect the character selected, e.g. in complete inbreeding or homogamy. Selection is very ineffective on autosomal recessive characters so long as they are rare.

Reprinted fromTransactions of the Cambridge Philosophical Society, Vol 23, pp. 19–41 (1924) with the permission of Cambridge University Press.