European Journal of Clinical Pharmacology

, Volume 32, Issue 6, pp 635–637

Differential efficacy of mebendazole and albendazole againstNecator americanus but not forTrichuris trichiura infestations

  • B. R. Holzer
  • F. J. Frey
Short Communications

DOI: 10.1007/BF02456002

Cite this article as:
Holzer, B.R. & Frey, F.J. Eur J Clin Pharmacol (1987) 32: 635. doi:10.1007/BF02456002


The effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, withT. trichiura and/orN. americanus infestation has been studied. Both albendazole and mebendazole cured more than 90% ofT. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate forN. americanus infestations.

Thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects withT. trichiura and/orN. americanus infestations.

Key words

Necator americanusTrichuris trichiuramebendazolealbendazole

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • B. R. Holzer
    • 1
  • F. J. Frey
    • 1
  1. 1.Medizinische PoliklinikUniversity of BerneThunSzitzerland