Short Communications

European Journal of Clinical Pharmacology

, Volume 32, Issue 6, pp 635-637

First online:

Differential efficacy of mebendazole and albendazole againstNecator americanus but not forTrichuris trichiura infestations

  • B. R. HolzerAffiliated withMedizinische Poliklinik, University of Berne
  • , F. J. FreyAffiliated withMedizinische Poliklinik, University of Berne

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The effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, withT. trichiura and/orN. americanus infestation has been studied. Both albendazole and mebendazole cured more than 90% ofT. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate forN. americanus infestations.

Thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects withT. trichiura and/orN. americanus infestations.

Key words

Necator americanus Trichuris trichiura mebendazole albendazole