, Volume 23, Issue 6, pp 525-535

Mathematical model of the human renal system

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A mathematical model is presented which provides an overall description of the renal/body fluid system, comprising an interconnected set of physiologically based representations of the relevant subsystems of the human organism. The model is used to test a number of hypotheses relating to the dynamics and control of the human renal system, including dynamics of ADH clearance, glomerular tubular balance and the control of the rate of release of ADH. Results are presented establishing the validity of the model in a number of empirical tests.