Original Communication

Journal of Neurology

, Volume 243, Issue 2, pp 137-142

First online:

Neurological complications of liver transplantation

  • Maria GuarinoAffiliated withServizio di Neurologia, Policlinico S. Orsola-Malpighi
  • , Andrea StracciariAffiliated withServizio di Neurologia, Policlinico S. Orsola-Malpighi
  • , Paolo PazzagliaAffiliated withServizio di Neurologia, Policlinico S. Orsola-Malpighi
  • , Roberto SterziAffiliated withDivisione di Neurologia, Ospedale Niguarda
  • , Ignazio SantilliAffiliated withDivisione di Neurologia, Ospedale Niguarda
  • , Franca DonatoAffiliated withDivisione di Neurologia, Ospedale Niguarda
  • , Roberto D’AlessandroAffiliated withServizio di Neurologia, Policlinico S. Orsola-Malpighi

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Abstract

We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.

Key words

Liver transplantation Mental status Seizures Peripheral neuropathy