Journal of Neurology

, Volume 243, Issue 2, pp 137–142

Neurological complications of liver transplantation

Authors

  • Maria Guarino
    • Servizio di NeurologiaPoliclinico S. Orsola-Malpighi
  • Andrea Stracciari
    • Servizio di NeurologiaPoliclinico S. Orsola-Malpighi
  • Paolo Pazzaglia
    • Servizio di NeurologiaPoliclinico S. Orsola-Malpighi
  • Roberto Sterzi
    • Divisione di NeurologiaOspedale Niguarda
  • Ignazio Santilli
    • Divisione di NeurologiaOspedale Niguarda
  • Franca Donato
    • Divisione di NeurologiaOspedale Niguarda
  • Roberto D’Alessandro
    • Servizio di NeurologiaPoliclinico S. Orsola-Malpighi
Original Communication

DOI: 10.1007/BF02444004

Cite this article as:
Guarino, M., Stracciari, A., Pazzaglia, P. et al. J Neurol (1996) 243: 137. doi:10.1007/BF02444004

Abstract

We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.

Key words

Liver transplantationMental statusSeizuresPeripheral neuropathy

Copyright information

© Springer-Verlag 1996