Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 6, pp 595–597

Effect of salicylates on the toxicity of GABA-lytics in mice

  • A. I. Golovko
  • G. A. Sofronov
  • T. V. Klyuntina
Biophysics and Biochemistry

DOI: 10.1007/BF02443698

Cite this article as:
Golovko, A.I., Sofronov, G.A. & Klyuntina, T.V. Bull Exp Biol Med (1995) 119: 595. doi:10.1007/BF02443698

Abstract

Preliminary injection of aspirin and salicylic acid increases the toxicity of picrotoxin, but not of bicuculline. Aspirin inhibits binding of3H-diazepam and N-methyl-3H-methylphenazepam with membranes from the brain of intact mice. In view of the fact that salicylates reduce the content and sorption capacity of serum albumin, this protein can be assumed to be involved in the detoxication of picrotoxin.

Key Words

GABA-lyticssalicylatestoxicityreceptorsSerum albumin

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • A. I. Golovko
    • 1
  • G. A. Sofronov
    • 1
  • T. V. Klyuntina
    • 1
  1. 1.Military Medical AcademySt. Petersburg